Serum IGF-I and C-reactive protein in healthy black and white young men: The CARDIA male hormone study |
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Authors: | Laura A. Colangelo Brian Chiu Peter Kopp Kiang Liu Susan M. Gapstur |
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Affiliation: | aDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 North Lake Shore Drive, Suite 1102, Chicago, IL 60611, United States;bThe Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, United States;cDepartment of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, United States |
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Abstract: | ObjectiveAnimal and human studies suggest that C-reactive protein (CRP) may be inversely associated with serum insulin-like growth factor-I (IGF-I) concentrations. However, most human studies have not controlled adequately for confounding factors, particularly nutritional intake. This population-based study examined whether CRP is inversely associated with IGF-I and IGFBP-3 concentrations.MethodsIn cross-sectional analysis, multivariable linear regression with adjustment for age, BMI, smoking status, alcohol intake, and nutritional factors was used to relate log CRP, the independent variable, to IGF-I and IGFBP-3 in a sample of black (n = 364) and white men (n = 486) separately by race.ResultsOnly black men had positive findings: log CRP was significantly associated with IGF-I (β = ?13.1 ng/ml, p = 0.02) and the difference in mean IGF-I concentrations between the highest and lowest quartiles of CRP was 26 ng/ml. There was a statistically significant interaction between log CRP and smoking status (p = 0.02); the regression coefficient for IGF-I predicted from log CRP was significant in smokers (β = ?39.8 ng/ml, p = 0.0001), but not in non-smokers. The difference in mean IGF-I concentrations between highest and lowest quartiles of CRP was 100 ng/ml for black smokers. There were no associations for IGFBP-3.ConclusionsIn our study, CRP levels are inversely associated with IGF-I concentrations in black male smokers; however, the causal nature of the association is unclear and should be studied further. |
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Keywords: | Insulin-like growth factor-I Insulin-like growth factor binding protein-3 C-reactive protein Men |
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