米氮平与氯丙咪嗪治疗妇女更年期情绪障碍的临床对照研究

目的　探讨米氮平对妇女更年期情绪障碍的临床疗效及副反应。方法　对 41例妇女更年期情绪障碍患者应用米氮平 ( 2 1例 )和氯丙咪嗪 ( 2 0例 )进行 6周开放性治疗。采用 HAMD、HAMA评定临床疗效 ,同时记录出现的药物副作用。结果　米氮平组与氯丙咪嗪组疗效近似 ,两组相比 ,差异无显著性 ( P>0 .0 5 ) ;两组的 HAMD、HAMA评定治疗前后相比 ,差异均显著 ( P<0 .0 5 ) ;米氮平起效快、副反应少且轻微。结论　米氮平与氯丙咪嗪对妇女更年期情绪障碍均有较好疗效 ,但米氮平具有起效快 ,用药简便 ,副反应轻微等优点

Clinical study of Mirtazapine and Clomipramine in Women Involutional Emotional Disorder

Objective To explore clinical efficcy and side effect of mirtazapine in women involutional emotional disorder.Methods Six-week open treatment was conducted in 41 female patients with involutional emotional disorder using mirtazapine(n=21)or clomipramine(n=20)respectively,clinical efficacy rated with HAMD and HAMA,and side effects were recorded.Results Mirtazapine had similar efficacy to clomipramine,and the comparison of the two groups showed no significant difference(P>0.05);the comparisons of pre-and post-treatment for both 2 groups in the HAMD and HAMA showed significant difference(P<0.05);mirtazapine took effect fast and had less and mild side reactions.Conclusion Both of mirtazapine and clomipramine have better efficacy on involutional emotional disorder,but mirtazapine has such merits as taking effect fast,administrating simply and less side reactions etc.