多囊卵巢综合征患者血纤溶能力的研究

目的了解多囊卵巢综合征(PCOS)患者的血纤溶能力及服用二甲双胍后血纤溶能力的变化。方法(1)对照组20例、PCOS患者30例,分别取血检测组织纤溶酶原激活物(t-PA)、纤溶酶原激活抑制物(PAI-1)的活性;(2)PCOS高胰岛素血症者10例,分别给予二甲双胍750~1 500 mg/d治疗,比较治疗前、后t-PA、PAI-1活性。结果PCOS组的血胰岛素(INS)、游离睾酮(F-T)t、-PA、PAI-1分别为(24.42±12.30)mU/L(、2.70±1.50)ng/L、(0.17±0.06)KU/L(、0.88±0.05)AU/ml,对照组分别为(10.04±6.12)mU/L(、1.70±1.00)ng/L(、0.28±0.04)KU/L、(0.70±0.09)AU/ml。10例PCOS患者经二甲双胍治疗后INS、F-Tt、-PA、PAI-1分别为(12.20±7.78)mU/L、(1.70±1.00)ng/L、(0.26±0.08)KU/L、(0.70±0.35)AU/ml。结论PCOS患者的血纤溶能力低于正常者,而服用二甲双胍后血纤溶能力明显改善。

The plasminogen ability in women with polycystic ovary syndrome

Objective: To evaluate the plasminogen activator system in women with polycystic ovary syndrome(PCOS) and determine whether metformin would increase the plasminogen activation in PCOS patients.Methods:(1) Serum free-testosterone(F-T),insulin(INS),tissue plasminogen activator(t-PA),plasminogen activator inhibitor type-1(PAI-1) activity of thirty women with PCOS and twenty controls were measured.(2) F-T,INS,t-PA,PAI-1 were also measured before and after a month oral administration of metformin 750~1 500 mg daily in ten PCOS women with hyperinsulinism.Results: The women with PCOS had higher serum levels of insulin(±s):(24.42±12.30)(mU/L,)higher F-T(2.70±1.50)ng/L,lower t-PA(0.17±0.06)KU/L and higher PAI-1(0.88±0.05)AU/ml than controls(10.04±6.12)mU/L,(1.70 ±1.00)ng/L,(0.28±0.04)KU/L,(0.70±0.09)AU/ml,respectively.The indices of serum INS,F-T,(t-PA) and PAI-1 were significantly improved after one month of metformin administration in the PCOS patient with(hyperinsulinism.)Conclusion: The fibrolysis activity is lower in women with PCOS and could be improved by(metformin.)