| TFF1TFF2在胃癌和癌前病变中的表达及意义 |
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| 引用本文： | 蔡建庭, 石淑青. TFF1TFF2在胃癌和癌前病变中的表达及意义[J]. 中国肿瘤临床, 2004, 31(20): 1163-1166. |
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| 作者姓名： | 蔡建庭 石淑青 |
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| 作者单位： | 浙江大学医学院附属第二医院消化内科 杭州市 310009 |
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| 摘 要： | 目的 :观察三叶因子I(Trefoilfactor1,TFF1)、三叶因子II(Trefoilfactor2,TFF2)在胃癌前病变(不典型增生和肠上皮化生)及胃癌的表达,探讨TFF1、TFF2表达与胃癌发生的关系。 方法 :对正常胃粘膜、胃粘膜肠上皮化生、胃癌组织各30例,采用SP免疫组化方法进行TFF1、TFF2蛋白的定位和半定量检测。 结果 :正常胃粘膜→肠上皮化生→不典型增生→胃癌四种病变中,TFF1、TFF2表达呈逐渐减弱趋势,差异具有显著性(P<0.05)。 结论 :TFF1、TFF2蛋白表达在胃癌发生过程中进行性下调,TFF1、TFF2蛋白表达可作为胃癌生物学行为的客观指标。
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| 关 键 词： | 三叶因子 胃癌 免疫组织化学 |
| 文章编号： | 1000-8179(2004)20-1163-04 |
| 收稿时间： | 2003-10-20 |
| 修稿时间： | 2004-06-18 |
Expression of Trefoil Factor 1, Trefoil Factor 2 in Gastric Cancer and Precancerous Lesion |
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| Cai Jianting, Shi Shuqing. Expression of Trefoil Factor 1,Trefoil Factor 2 in Gastric Cancer and Precancerous Lesion[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2004, 31(20): 1163-1166. |
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| Authors: | Cai Jianting Shi Shuqing |
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| Affiliation: | Department of Gastroenterology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou |
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| Abstract: | Objective :To investigate the expression of trefoil factor 1,trefoil factor 2 in gastric cancer and precancerous lesion,thus to investigate the relationship of TFF1、TFF2 expression and the pathogenesis of gastric cancer. Methods :The expression of TFF1,TFF2 was determined by immuno-histochemical method in 120 gastric specimens including normal gastritic mucosa (30 specimens),intestinal metaplasia in gastric mucosa (30 specimens),displasic gastric mucosa (30 specimens) and gastric carcinomas (30 specimens). Results :In normal contral group,precancerous group and gastric carcinoma group,the level of TFF1 and TFF2 expression had a decreasing tendency (P<0.05). Conclusion :The expression of TFF1, TFF2 protein was dowen regulated in the process of gastric cancer. |
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| Keywords: | Trefoil factor Gastric cancer Immunohistochemistry |
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