急性心肌梗死病人补体活化片段浓度的动态变化

目的探讨急性心肌梗死（ＡＭＩ）病人血浆补体活化片段浓度的动态变化及意义。②方法采用酶联免疫吸附法（ＥＬＩＳＡ），检测了６７例ＡＭＩ病人发病第１，４，７天时和３８例健康人、４２例陈旧性心肌梗死（ＯＭＩ）病人血浆补体活化片段（ｓＣ５ｂ－９）浓度的变化。③结果ＡＭＩ病人ｓＣ５ｂ－９浓度明显增高，与对照组和ＯＭＩ病人比较差异有极显著性（Ｆ＝１８．６７３，ｑ＝８．４２３～１６．８５１，Ｐ＜０．００１）。发病第１，４，７天，ｓＣ５ｂ－９浓度逐渐降低，差异有极显著性（Ｆ＝１４．６２８，ｑ＝６．２７５～１４．１６２，Ｐ＜０．００１）。病死者和伴有室性心律失常者ｓＣ５ｂ－９增高较存活者和无室性心律失常者更明显（ｔ＝１３．６４９，８．３９５，Ｐ＜０．００１）。④结论补体活化片段浓度的动态变化参与了ＡＭＩ的发生和发展，且与病情严重程度和预后有密切关系。

DYNAMIC CHANGES OF CONCENTRATION OF COMPLEMENT ACTIVATION COMPOSITION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

Objective To explore the dynamic changes and clinical significances of concentration of complement activation composition in patients with acute myocardial infarction (AMI). Methods By means of enzyme linked immunosorbent assay (ELISA), the changes of concentration of complement activation composition (sC 5b 9) were measured in 67 patients with AMI on the 1st,4th and 7th days after onset of AMI, 42 patients with old myocardial infarction ( OMI) and 38 healthy subjects. Results The concentration of sC 5b 9 were higher in AMI patients than that in controls and OMI patients ( F=18.673,q=8.423- 16.851 ,P< 0.001), while on the 1st,4th and 7th days in AMI patients, the high concentration of sC 5b 9 decreased gradually ( F= 14.628 ,q=6.275-14.162,P <0.001). The concentration of sC 5b 9 was higher in patients with ventricular arrhythemia (VA) and the dead patients before the 4th day than that in patients without VA and the survivals ( t=13.649, 8.395,P <0.001). Conclusion The dynamic changes of concentration of complement activation composition may participate in the occurance and development of AMI,and have close relation to the seriouness of patients' condition and the prognosis.