| β-内啡肽抑制急性低氧暴露大鼠下丘脑促甲状腺素释放激素的释放(英文) |
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| 引用本文： | 侯天德,杜继曾.β-内啡肽抑制急性低氧暴露大鼠下丘脑促甲状腺素释放激素的释放(英文)[J].中国药理学报(英文版),2002(10). |
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| 作者姓名： | 侯天德 杜继曾 |
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| 作者单位： | 西北师范大学生命科学学院生理学教研室，浙江大学生命科学学院神经生物学与生理学教研室 兰州 730070，杭州，中国 310027 |
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| 基金项目： | Project supported by the National Natural Science Foundation of China(№ 30070289)and the Science and Knowledge Innova-tion Project of Northwest Normal University(№ 2). |
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| 摘 要： | 目的:研究β-内啡肽对急性低氧暴露下清醒大鼠下丘脑正中隆起和室旁核促甲状腺素释放激素(TRH)应答的影响.方法:放射免疫法测定脑组织TRH和血清T_3、T_4含量.雄性大鼠放置于低压舱中,模拟海拔7000米(8.2％ O_2),低氧暴露时间2 h.低氧暴露前,侧脑室注射β-内啡肽.结果:侧脑室分别注射β-内啡肽0.l和1μmol/L使低氧暴露大鼠下丘脑正中隆起TRH含量分别比生理盐水组(4.8±0.3)μg/g蛋白]升高12％(P<0.05)和15％(P<0.0 5),室旁核TRH含量分别比生理盐水组(180±21)ng/g蛋白]升高24％(P<0.05)和44％(P<0.01),血清 T_3、T_4浓度降低(P<0.05或P<0.01).纳洛酮10 μmol/L拮抗了 β-内啡肽0.1μmol/L对室旁核和正中隆起TRH含量升高以及血清T_3、T_4降低的效应.单独脑室注射纳洛酮10 μmol/L使下丘脑正中隆起和室旁核TRH减少(P<0.05或P<0.01),而血清T_3、T_4浓度升高(P<0.01).结论:β-内啡肽通过抑制正中隆起和室旁核TRH释放机制参与急性低氧暴露大鼠下丘脑TRH分泌的调节.
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| 关 键 词： | β-内啡肽 促甲状腺素释放激素 纳洛酮 低氧 正中隆起 下丘脑室旁核 脑室内注射 |
Beta-endorphin suppresses release of thyrotropin-releasing hormone in rat hypothalarn0us during acute hypoxia exposure |
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| HOU Tian-De,DU Ji-ZengDivision of Physiology,College of Life Sciences,Northwest Normal University,Lanzhou , Division of Neurobiology and Physiology,College of Life Sciences,Zhejiang University,Hangzhou ,China.Beta-endorphin suppresses release of thyrotropin-releasing hormone in rat hypothalarn0us during acute hypoxia exposure[J].Acta Pharmacologica Sinica,2002(10). |
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| Authors: | HOU Tian-De DU Ji-ZengDivision of Physiology College of Life Sciences Northwest Normal University Lanzhou Division of Neurobiology and Physiology College of Life Sciences Zhejiang University Hangzhou China |
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| Institution: | HOU Tian-De,DU Ji-ZengDivision of Physiology,College of Life Sciences,Northwest Normal University,Lanzhou 730070, Division of Neurobiology and Physiology,College of Life Sciences,Zhejiang University,Hangzhou 310027,China |
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| Abstract: | |
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| Keywords: | beta-endorphin thyrotropin-releasing hormone naloxone hypoxia median eminence paraventricular hypothalamic nucleus intraventricular injections |
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