毓宫胶囊对肾阳虚型子宫发育不良大鼠IL2-IFN-NKC免疫调节网影响的研究

【目的】观察毓官胶囊对肾阳虚型子宫发育不良大鼠IL2（自介素-2）-IFN（干扰素）-NKC（自然杀伤细胞）免疫调节网的影响，探讨其治疗子宫发育不良的机制。【方法】通过对幼龄SD雌鼠40只随机分为4组：正常对照组（A组）、模型组（B组）、右归丸组（C组）、毓宫胶囊组（D组），肌注地塞米松复合双侧卵巢切除建立肾阳虚型子宫发育不良模型，对模型动物用毓宫胶囊治疗，右归丸做对照，治疗18d后处死，取胸腺、脾脏、子宫称质量，并测定脾组织IL2、IFN、NKC活性。【结果】肾阳虚子宫发育不良大鼠胸腺、脾脏、子宫质量以及IL2、IFN、NKC活性均较正常组明显下降（P〈0．01），毓宫胶囊能提高胸腺、脾脏、子宫质量及IL2、IFN、NKC活性（P〈0．01）。【结论】肾阳虚型子宫发育不良大鼠的非特异性免疫力下降；毓宫胶囊在促进肾阳虚型子宫发育不良大鼠子宫发育的同时，提高IL2、IFN、NKC活性，正向调节其免疫功能。即毓宫胶囊有调节神经内分泌免疫网的作用。

Influence of Yugong Capsule on IL-2-IFN-NKC Immunological Regulation Network in Rats with Deficiency of Kidney-Yang Syndrome and Dysplasia of Uterus

Objective] To observe the influence of Yugong(invigorating the uterus)Capsule on IL₂-IFN-NKC immunological regulation network in rats with deficiency of kidney-yang syndrome and dysplasia of uterus and discuss the mechanism of treating dysplasia of uterus.Methods] Forty immature SD female mice were randomly divided into four groups:control group(A),model group(B),Yougui pills group(C),Yugong capsule(D).The deficiency kidney-yang syndrome and dysplasia of uterus in rats were established by injecting hexadecadrol and bilateral oophorectomy.The weight of thymus,spleen,uterus,the IL-2,IFN and NKC activity of the spleen were determined.Result] The weight of thymus,spleen uterus and IL-2,IFN and NKC activity in the treatment group were obviously lower than that in the normal group in rays with deficiency of kidney-yang syndrome and dysplasia of uterus(P<0.01).Yugong Capsule could increase the weight of thymus,spleen,uterus and IL-2,IFN and NKC activity(P<0.01).Conclusion] Nonspecific immunity decreased in rats with deficiency of kidney-yang syndrome and hypoplasia of uterus.Yugong Capsule can promote the development of uterus,enhance IL-2,IFN and NKC activity and up-regulate its immune function in rats with deficiency of kidney-yang syndrome and sysplasia of uterus.YuGong capsule possesses a regulative effect on nerve-endocrine-immune networks.