The effect of praziquantel on the pseudophyllidean cestodeBothriocephalus acheilognathi in vitro |
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Authors: | D W Pool |
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Institution: | (1) Department of Zoology, The University of Liverpool, P.O. Box 147, L69 3BX Liverpool, UK |
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Abstract: | AdultBothriocephalus acheilognathi were incubated in solutions containing 0 (control), 0.1, 1.0, 10.0 and 100 g praziquantel per ml (0, 102, 103, 104 and 105 gl–1) of 0.9% saline for 5, 15 and 60 min at a temperature of 18°C. The worms contracted immediately upon being placed in the drug. Scanning and transmission electron microscopy revealed considerable tegumental damage particularly in the neck region. Vacuolization and bubbling to the tegument occurred in all of the drug solutions tested. Exposure to drug concentrations of more than 1.0 gml–1 (103 gl–1) praziquantel for 15 min or greater resulted in many of the bubbles bursting and releasing their contents to the exterior. Mature proglottides were distorted and had occasional large swellings resulting in the mass expulsion of eggs. Praziquantel had no ovicidal activity. Exposure to drug concentrations of 100 g (105 gl–1) praziquantel per ml saline for 24 h was not lethal to the worms. |
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