丹归消肿膏外敷对大鼠急性软组织损伤的消肿止痛作用

目的 观察丹归消肿膏外敷对造模大鼠急性软组织损伤的消肿止痛作用.方法 选取36只Wistar大鼠,随机分为模型组(A组)、辽源七厘散组(B组)、丹归消肿膏组(C组).A组大鼠涂基质软膏,B组涂辽源七厘散,C组涂丹归消肿膏,2次/d,分别涂抹7 d后,观察角叉菜胶引起足肿胀的程度和对痛阈值的影响.结果 注射0.8%角叉菜胶0.1 mL/只1、2、4、5、6 h后B、C组与A组比较,足肿胀程度明显降低(P<0.01,P<0.05);B、C组比较注射后足肿胀程度无明显变化.检测大鼠痛阈值的改变观察药物的镇痛作用,B、C组大鼠痛阈值高于A组(P<0.01,P<0.05),C组的大鼠痛阈值高于B组(P<0.01,P<0.05).结论 丹归消肿膏治疗大鼠急性软组织损伤能有效抑制足肿胀和明显镇痛,消肿止痛.

Effect of Dangui Xiaozhong ointment on acute soft tissue injury in rat models

Objective To observe the effect of external using Dangui Xiaozhong ointment in treating acute soft tissue injury (ASTI) in rat models. Methods 36 Wistar rats were randomly divided into model group (A), Liaoyuan Qilisan group (B) and Dangui Xiaozhong ointment group (C). Group A rats were coated with matrix ointment, B group was coated with Liaoyuan Qilisan and group C was treated with Dangui Xiaozhong ointment, 2 times /d. To observe the degree of foot swelling caused by carrageenin and its influence on pain threshold after 7 days. Results There was difference reduce in foot swelling of B, C groups than A group at 1, 2, 4, 5, 6 hour (P<0.01, P<0.05). B, C group after the injection of foot swelling had no obvious change. The analgesic effect of the drug was detected by detecting the change of the pain threshold in rats.B,C groups were higher than A group in pain threshold (P<0.01, P<0.05). C groups were higher than B group in pain threshold (P<0.01, P<0.05). Conclusion Dangui Xiaozhong ointment treatment of acute soft tissue injury in rats can effectively inhibit foot swelling and obvious analgesic effect, swelling and pain relief