复方榴莲皮软膏对特应性皮炎患者皮肤屏障功能修复的临床研究

目的:观察复方榴莲皮软膏对特应性皮炎患者皮肤屏障功能修复的影响。方法:将120例符合要求的特应性皮炎患者随机分为两组,治疗组予外用复方榴莲皮软膏,对照组予外用0.1%糠酸莫米松乳膏,并于治疗第0周、第2周、第4周比较两组SCORAD评分、VAS评分、角质层含水量、PH值、TEWL等指标。结果:治疗4周后治疗组患者SCORAD评分、VAS明显下降,与对照组比较有明显差异(P0.05);皮损处角质层含水量明显高于对照组,PH值、TEWL值下降程度明显优于对照组(P0.05)。结论:复方榴莲皮软膏治疗特应性皮炎疗效确切,可有效改善皮肤屏障功能,远期疗效好,且无不良反应。

Clinical Study of Compound Durian Skin Ointment Repairing Skin Barrier in Patients with Atopic Dermatitis

Objective:to observe the effect of Compound Durian Skin Ointment on repairing skin barrier in patients with atopic dermatitis.Methods: 120 patients with atopic dermatitis were randomly divided into two groups: treatment group treated with Com-pound Durian Skin Ointment while control group with 0.1% Mometasone Furoate Cream.On the zeroth week, second week, and fourth week, SCORAD score, VAS score, the stratum corneum water content, pH value, TEWL and other indicators were compared. Results: 4 weeks after treatment, SCORAD score and VAS score of treatment group decreased significantly, and there was significant difference compared to control group ( P <0.05); the stratum corneum water content was higher than that of control group, PH value and TEWL decreased significantly with superior effect to control group ( P <0.05).Conclusion:Compound Durian Skin Ointment can treat atopic dermatitis with curative effect, and can effectively improve skin barrier function with good long-term effect, and no adverse reaction.