原发性肝癌与HBV、HCV感染关系

目的 研究东北地区原发性肝癌发生的危险因素,尤其是乙型肝炎病毒(HBV)感染、丙型肝炎病毒(HCV)感染与原发性肝癌的关系。方法 收集2005年10月~2007年4月在中国医科大学附属第一医院住院的原发性肝癌患者作为病例组,同时期住院的血管疾病患者作为对照组,记录其血清HBV、HCV标志物和既往肝炎、肝硬化及家族史等情况进行病例对照研究。结果 原发性肝癌组222例,HBV感染率为68.92%,明显高于对照组7.49%(χ2=200.1,P<0.0001),优势比OR=27.4(95%CI=16.0~46.9);HCV感染病例组(15.32%)也明显高于对照组(1.12%)χ2=34.9,P<0.0001,OR=15.9。此外,原发性肝癌还与既往肝硬化史、家族肝癌史有关,且以男性高发。结论 原发性肝癌的发生受多种因素影响,尤其HBV和/或HCV慢性感染是主要危险因素之一。

Relationship between primary hepatocellular carcinoma and HBV and HCV infection

Objective To study the risk factors,especially focusing on HBV and HCV of primary hepatocellular carcinomain Northeast.Methods Cases of primary hepatocellular carcinoma(PHC)and vascular disease were sampled in No.1 Affiliated Hospital of China Medical University from October,2005 to April,2007.Then a case-control study was carried on serum markers of HBV and HCV and the history of hepatitis,cirrhosis.Results The total infection rate of HBV in hepato cellular carcinoma cases was 68.92% and 7.49% in vascular disease cases.There was a significant diffence(χ²=200.1,P< 0.0001)in total infection of HBV between cases and controls and the odds ratio calculated was 27.4(95%CI:16.0-46.9).The same difference existed in HCV infection.Moreover,the history of hepatitis B and cirrhosis were also found relating to PHC.Conclusion There are several factors relative to PHC,and the main risk factors are HBV and HCV infection.