Kinematic biomechanical assessment of human articular cartilage transplants in the knee using 3-T MRI: an in vivo reproducibility study |
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Authors: | Vladimir Juras Goetz H Welsch Steven Millington Pavol Szomolanyi Tallal C Mamisch Katja Pinker Siegfried Trattnig |
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Institution: | (1) Department of Radiodiagnostics, MR Centre of Excellence, Medical University of Vienna, Lazarettgasse 14, 1090 Vienna, Austria;(2) Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Dubravska cesta 9, 841 04 Bratislava, Slovak Republic;(3) Royal National Orthopaedic Hospital, Brockley Hill, London, Stanmore, HA7 4LP, UK;(4) Orthopedic Surgery Department, Inselspital, 3010 Berne, Switzerland;(5) Austrian Cluster for Tissue Regeneration, Ludwig Boltzmann Institute for Clinical and Experimental Traumatology, Vienna, Austria |
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Abstract: | The aims of this study were to examine the clinical feasibility and reproducibility of kinematic MR imaging with respect to
changes in T
2 in the femoral condyle articular cartilage. We used a flexible knee coil, which allows acquisition of data in different positions
from 40° flexion to full extension during MR examinations. The reproducibility of T
2 measurements was evaluated for inter-rater and inter-individual variability and determined as a coefficient of variation
(CV) for each volunteer and rater. Three different volunteers were measured twice and regions of interest (ROIs) were selected
by three raters at different time points. To prove the clinical feasibility of this method, 20 subjects (10 patients and 10
age- and sex-matched volunteers) were enrolled in the study. Inter-rater variability ranged from 2 to 9 and from 2 to 10%
in the deep and superficial zones, respectively. Mean inter-individual variability was 7% for both zones. Different T
2 values were observed in the superficial cartilage zone of patients compared with volunteers. Since repair tissue showed a
different behavior in the contact zone compared with healthy cartilage, a possible marker for improved evaluation of repair
tissue quality after matrix-associated autologous chondrocyte transplantation (MACT) may be available and may allow biomechanical
assessment of cartilage transplants. |
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Keywords: | MR imaging/diagnosis MR imaging/kinematics Transplantation Chondrocytes Autologous |
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