Q-开关Nd:YAG激光1064nm联合还原型谷胱甘肽治疗黄褐斑的临床疗效分析

目的:探讨Q-开关Nd:YAG激光1 064nm联合还原型谷胱甘肽治疗黄褐斑的临床疗效。方法:选取黄褐斑患者62例。将患者随机分为治疗组及对照组各31例。对照组单纯应用Q-开关Nd:YAG激光1 064nm治疗;治疗组在应用Q-开关Nd:YAG激光1064nm治疗的同时联合应用还原型谷胱甘肽(GSH)0.9g,加入生理盐水250ml静滴,每日1次,每次激光治疗后连续点滴5日。结果:治疗组基本治愈12例,显效16例,好转3例,无效0例,总有效率为90.3%,对照组基本治愈9例、显效13例、好转7例、无效2例,总有效率70.9%,两组疗效比较(P0.05),差异有统计学意义。结论:Q-开关Nd:YAG激光1 064nm联合还原型谷胱甘肽治疗黄褐斑疗效确切,安全性高,无明显副作用,是一种安全、有效的治疗方法。

Clinical observation of using 1064nm Q-switched Nd. YAG laser combined with reduced glutathione in treating melasma

Objective To observe the 1 064rim Q-switched Nd.YAG laser combined with reduced glutathione treating melasma. Methods 62 patients with melasma were randomly divided into two groups.Each group had 31 cases, control group were treated by 1 064nm Q-switch Nd：YAG laser only;treatment group were treated with 1 064rim Q-switched laser combined with reduced glutathione.Results The total effective rate,basically cured cases,markedly effective cases,improved cases, uneffective cases were 90.3,12,16,3,0 respectively in treatment group;70.9,9,13,7,2 respectively in control group.The difference of two groups after statistics was significant （P〈0.05）. Conclusion 1064nm Q-switched laser combined with reduced glutathione is a useful new treatment modality of melasma with precise efficacy,less side effects and high safety.