外用普萘洛尔和噻吗洛尔治疗婴幼儿颜面部血管瘤疗效比较观察

目的:观察外用盐酸普萘洛尔和噻吗洛尔治疗婴幼儿颜面部增生期血管瘤的临床疗效并进行比较。方法:43例颜面部血管瘤患儿,按治疗方法不同分为普萘洛尔治疗组(23例)和噻吗洛尔治疗组(20例),两组分别门诊使用盐酸普萘洛尔注射液或噻吗洛尔滴眼液于血管瘤体表涂抹,3次/天,治疗4~16周后评价疗效,同时观察两组患儿用药后的不良反应并比较两种药物的临床使用安全性。结果:普萘洛尔治疗组:23例,Ⅳ级疗效8例(34.8%),III级6例(26.1%),II级5例(21.7%),I级4例(17.4%);噻吗洛尔治疗组:20例,Ⅳ级疗效7例(35.0%),III级6例(30.0%),II级4例(20.0%),I级3例(15.0%)。所有患儿均未见明显不良反应发生。结论:外用盐酸普萘洛尔和噻吗洛尔治疗婴幼儿颜面部增生期血管瘤均有一定的疗效,临床显效率无明显差异。

The clinical observation and comparion of propranolole and timolol for infant facial hemangioma

Objective Observe and compare the clinical effects between propranolole hydrochloride and timolol for infant facial hemangioma.Methods Forty-three childern who were beset with infant facial hemangioma were devided into two groups,the propranolole group and timolol group according to different treatment,and there were twenty-three and twenty infants repectively.All the infants received the treatment three times per day,and the treatment time duration varied from 4 weeks to 16 weeks.According to the changes of the size,color and tension of the hemangioma,the treatment effects can be divided into effectual,partial effectual and invalid.Results The propranolole group,8 cases were Ⅳ grade curative effect,6cases were Ⅲ grade curative effect,5 cases were Ⅱ grade curative effect,and 4 cases were Ⅰ grade curative effect; and the timolol group,7 cases were Ⅳ grade curative effect,6cases were Ⅲ grade curative effect,4 cases were Ⅱ grade curative effect,and 3 cases were Ⅰ grade curative effect.All the infants have no drug adverse reaction.Conclusions Propranolole hydrochloride and timolol are both effctive for infant facial hemangioma,no discrepancy of clinical effective rate.