Changes of intraocular pressure after intravitreal
injection of 4mg triamcinolone acetonide in treatment
of macular edema |
| |
Authors: | Li-Li Wang Hu-Ping Song and Bei Liu |
| |
Institution: | Department of Ophthalmology, the Fourth Hospital of Xi'an City,
Xi'an 710004, Shaanxi Province, China;Department of Ophthalmology, the Fourth Hospital of Xi'an City,
Xi'an 710004, Shaanxi Province, China;Department of Ophthalmology, the Fourth Hospital of Xi'an City,
Xi'an 710004, Shaanxi Province, China |
| |
Abstract: | AIM: To investigate the changes of intraocular pressure
(IOP) and associated factors of IOP elevation after 4mg
intravitreal injection of triamcinolone acetonide (IVTA) in
treatment of macular edema.
·METHODS: The study is prospective, consecutive, and
non-comparative interventional case series including 93 eyes
with macular edema associated with retinal vein occlusion
( =54 eyes) or diabetic retinopathy ( =39 eyes), which
received 4mg IVTA injection. The change in IOP was followed
for all cases at pre-operation and 14 days, 1, 2, 3, 4, 5, and 6
months post-operation. Associated factors of IOP elevation
were examined regarding baseline IOP, causal disease, age
and gender.
·RESULTS: IOP increased significantly ( <0.001) at 14 days
16.02 ± 2.45mmHg after injection and peaked at 18.80 ±
6.20mmHg at 2 months post-injection ( <0.001) from
14.85± 2.55 mmHg preoperatively. An IOP rise to the value
higher than 21mmHg was observed in 2 (2.2%) eyes 14 days
after injection and which was observed in 14 (15.1%), 18
(19.5%), 9(9.6%), 4(4.3%), 0, and 0 eyes respectively at 1,
2, 3, 4, 5, and 6 months after injection. One eye (1.07%)
showed pressure elevation of over 5mmHg than baseline 14
days after injection and IOP peaked to 22mmHg (23.7%) at 2
months after injection. Five (5.3%) eyes had an increase of
10mmHg at 1 month and IOP peaked to 12mmHg (12.9%) at
2 months after injection. The rise in IOP was statistically
associated with younger age (correlation coefficient -0.18-
-0.29, <0.05), high baseline IOP (correlation coefficient
0.52-0.79, all <0.001), and the presence of diabetes
mellitus (correlation coefficient 0.23, <0.001) but
independent of gender (correlation coefficient -0.002-0.04, all
>0.05). In all eyes, IOP could be lowered to the normal
range with topical medication, without development of
glaucomatous optic nerve head changes.
·CONCLUSION: Elevated IOP after 4mg IVTA injection is
common and patients should be monitored beyond 6 months
post-injection. In all the cases, IOP can be normalized by
topical medication. Patients with high baseline IOP, diabetic
retinopathy, and younger age should be carefully monitored
for an elevated IOP. |
| |
Keywords: | intraocular pressure intravitreal injections triamcinolone acetonide complication |
|
| 点击此处可从《国际眼科杂志(英文版)》浏览原始摘要信息 |
| 点击此处可从《国际眼科杂志(英文版)》下载免费的PDF全文 |
|