Corneal lymphangiogenesis correlates closely with hemangiogenesis after keratoplasty |
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Authors: | Shi-Qi Ling Can Liu Wei-Hua Li Jian-Gang Xu and Wen-Hui Kuang |
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Institution: | Department of Ophthalmology, Guangzhou Women and Children's Medical Center, Guangzhou 510120, Guangdong Province, China. |
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Abstract: | AIM: To examine the relationship between corneal lymphangiogenesis and hemangiogenesis after keratoplasty.
· METHODS: Nineteen human corneas were obtained from 19 patients undergoing a second corneal transplantation in Zhongshan Ophthalmic Center in 2005. Blood and lymphatic vessels in human transplanted corneas were identified by lymphatic vessel endothelial receptor (LYVE-1) and platelet endothelial cell adhesion modecule-1 (PECAM-1) immunohi- stochemistry, and double enzyme-histochemistry; then the association of corneal blood vessel counting (BVC) with lymphatic vessel counting (LVC) was examined.
· RESULTS: Corneal hemangiogenesis was present in 12 cases (63%), and lymphangiogenesis occurred in 5 cases (26%) human transplanted corneas. In addition, corneal lymphangiogenesis was only present in vascularized corneas. LVC was strongly and positively correlated with BVC(r=0.725, P <0.01).
· CONCLUSION: Corneal lymphangiogenesis develops after keratoplasty and strongly associates with hemangiogenesis. |
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Keywords: | cornea keratoplasty lymphangiogenesis hemangiogenesis |
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