免疫功能正常患者鼻眶部毛霉菌病的研究

目的：报告1例免疫功能正常患者鼻眶部毛霉菌病非典型病例，并对该病例进行相关文献回顾。患者，男，17岁，免疫功能正常，左眼2mo缓慢进行性疼痛肿胀。行组织活检，病理学诊断为毛霉菌病。采用综合疗法，包括筛窦及上颌窦侵入性内窥镜切除和清创、左眼眶内容物刮除术、静脉注射两性霉素B和眶内两性霉素B冲洗，成功根除真菌感染。该病例说明，鼻眶部毛霉菌病可发生在年轻健康的个体身上。早期诊断，积极的药物和手术治疗对成功地治疗这种罕见的具有潜在致命性的疾病是至关重要的。

Rhino-orbital mucormycosis in immunocompetent patient

We present an atypical case of rhino-orbital mucormycosis in an immunocompetent patient and a literature review on this topic. A 17-year-old immunocompetent male presented with 2-month history of painful slowly progressive swelling of the left eye. The diagnosis of mucormycosis was made by histopathological examination of tissue specimens. The patient had successful eradication of the fungal infection with the use of multiple treatment modalities including aggressive endoscopic excision and debridement of ethmoid and maxillary sinuses, left orbital exenteration, intravenous amphotericin B and intraorbital amphotericin B. This case suggests that rhino-orbital mucormycosis can occur in a young healthy individual. Early diagnosis with aggressive medical and surgical management is vital to successfully treat this rare and potentially fatal disease.