首页 | 本学科首页   官方微博 | 高级检索  
     

血清同型半胱氨酸和C反应蛋白与2型糖尿病周围血管病变的关系
引用本文:尹虹,辛燕,周彪. 血清同型半胱氨酸和C反应蛋白与2型糖尿病周围血管病变的关系[J]. 中国医师进修杂志, 2014, 0(1): 4-6
作者姓名:尹虹  辛燕  周彪
作者单位:兰州市第一人民医院内分泌科,730050
摘    要:目的观察血清同型半胱氨酸(Hcy)和C反应蛋白(CRP)与2型糖尿病周围血管病变(PVD)的关系。方法将58例2型糖尿病患者按是否伴有PVD分为单纯2型糖尿病组(DM组,30例)和PVD组(28例),另选健康体检者25例作为对照组,检测三组空腹血糖(FBG)、糖化血红蛋白(HbA,e)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、Hcy、CRP,并计算体质指数(BMI)及踝肱比等。结果三组BMI、TG、TC、HDL—C比较差异无统计学意义(P〉0.05)。DM组、PVD组FBG、HbA1c、LDL.C明显高于对照组[(7.54±1.25)、(8.12±1.57)mmol/L比(4.68±0.54)mmol/L,(6.92±0.89)%、(7.544-O.97)%比(4.80±0.54)%,(3.79±0.73)、(4.41±0.93)mmol/L比(2.68±0.54)mmol/L],差异有统计学意义(P〈0.05);但PVD组和DM组比较差异无统计学意义(P〉0.05)。DM组、PVD组Hcy、CRP明显高于对照组[(10.26±3.62)、(19.83±5.54)μmol/L比(8.92±2.41)μmol/L,(4.12±0.57)、(5.47±0.85)mg/L比(2.73±0.54)mg/L],踝肱比明显低于对照组(0.92士0.18、0.81±0.16比1.02±0.23),差异有统计学意义(P〈0.05);而且PVD组Hey、CRP明显高于DM组,踝肱比明显低于DM组,差异有统计学意义(P〈0.05)。Spearman分析结果显示,Hey与踝肱比呈负相关(r=-0.635,P〈0.05),CRP与踝肱比呈负相关(r=-0.529,P〈0.05),Hey与CRP呈正相关(r=0.528,P〈0.05)。偏相关分析结果显示,Hey与踝肱比仍呈负相关(r=-0.315,P〈0.05),CRP与踝肱比仍呈负相关(r=-0.243,P〈0.05)。结论ttcy和CRP参与了2型糖尿病PVD的发生和发展,可以作为2型糖尿病PVD的预测因子。

关 键 词:糖尿病并发症  半胱氨酸  C反应蛋白质

Relationship between homocysteine,C-reactive protein and type 2 diabetes peripheral vascular disease
Yin Hong,Xin Yah,Zhou Biao. Relationship between homocysteine,C-reactive protein and type 2 diabetes peripheral vascular disease[J]. Chinese Journal of Postgraduates of Medicine, 2014, 0(1): 4-6
Authors:Yin Hong  Xin Yah  Zhou Biao
Affiliation:. Department of Endocrinology,the First People's Hospital of Lanzhou City ,Lanzhou 730050, China
Abstract:Objective To observe the relationship between homocysteine (Hcy), C-reactive protein (CRP) and type 2 diabetes peripheral vascular disease (PVD). Methods Fifty-eight patients with type 2 diabetes according to the condition of PVD were divided into simple type 2 diabetes mellitus group (DM group, 30 cases ) and PVD group (28 cases). Twenty-five healthy people were chosen at the same period as control group. The fasting blood glucose (FBG), glycosylated hemoglobin (HbA,c), total cholesterol(TC), triglyceride (TG),high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C),Hcy and CRP levels were detected among 3 groups,and the body mass index (BMI), ankle brachial index(ABI) was calculated. Results The BMI,TG,TC and HDL-C levels among 3 groups had no statistical significance (P 〉0.05). The FBG,HbAjc and LDL-C in DM group and PVD group were significantly higher than those in control group [ (7.54 ± 1.25), (8.12 ± 1.57) mmol/L vs. (4.68 ± 0.54) mmol/L; (6.92 ± 0.89)%, ( 7.54 ± 0.97 )% vs. (4.80 ± 0.54 ) % ; ( 3.79 ± 0.73 ), (4.41 ±0.93 ) mmol/L vs. ( 2.68 ± 0.54 ) mmol/L ], and the difference was statistically significant (P 〈 0.05 ). But the difference betweenPVD group and DM group had no statistical significance (P 〉 0.05). Hcy and CRP in DM group and PVD group were higher than those in control group [ (10.26 ± 3.62), (19.83 ± 5.54) μ mol/L vs. (8.92 ± 2.41 ) mol/L; (4.12 ± 0.57 ), (5.47 ± 0.85 ) mg/L vs. (2.73 ± 0.54) mg/L ], ABI was lower than that in control group (0.92 ± 0.18,0.81 ± 0.16 vs. 1.02 ± 0.23 ), and the difference was statistically significant (P 〈 0.05 ) ; Hcy,CRP in PVD group were obviously higher than those in DM group, ABI was lower than that in DM group, and the differences were statistically significant (P 〈 0.05 ). Spearman analysis showed that Hey was negatively correlated with ABI (r = -0.635, P 〈 0.05 ), CRP was negatively correlated with ABI (r = -0.529, P 〈 0.05 ), and Hey was positively correlated with CRP (r = 0.528 ,P 〈 0.05 ). The partial correlation analysis results showed that Hey and ABI still showed a negative correlation (r = -0.315 ,P 〈 0.05), CRP and ABI still showed a negative correlation (r = -0.243,P 〈 0.05 ). Conehtsion Hcy and CRP participating in the occurrence and development of type 2 diabetes PVD, can be used as a predictor of type 2 diabetes PVD.
Keywords:Diabetes complications  Cysteine  C-reactive protein
本文献已被 维普 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号