扩张型心肌病患者心外膜脂肪厚度与左室重构的相关性研究

目的 探讨扩张型心肌病（DCM）患者的心外膜脂肪（EAT）厚度与左室重构及左室功能不全的关系.方法 116例DCM患者（DCM组）和76例健康体检者（对照组）均行超声心动图检查,测量或计算左室收缩末期内径（LVESD）、左室舒张末期内径（LVEDD）、左室收缩末期容积（LVESV）、左室舒张末期容积（LVEDV）、左室收缩末期容积指数（LVESVI）、左室舒张末期容积指数（LVEDVI）、左室射血分数（LVEF）、EAT厚度等,并进行比较分析.结果 DCM组EAT厚度为（4.7±1.2） mm,显著低于对照组的（7.6±2.1） mm,差异有统计学意义（P＜0.05）.经线性相关分析显示,EAT厚度与LVESD、LVEDD、LVESV、LVEDV、LVEDVI、LVESVI呈正相关（r=0.236,0.220,0.245,0.256,0.282,0.279,P＜0.05）,而与LVEF无相关性（r=0.134,P＞0.05）.结论 DCM患者的EAT厚度与左室重构明显相关,与左室功能不全无相关性.

Association between epicardial adipose tissue thickness and left ventricular remodeling in dilated cardiomyopathy

Objective To explore the association between epicardial adipose tissue （EAT） thickness and left ventricular remodeling,left ventricular dysfunction in dilated cardiomyopathy （DCM）.Methods One hundred and sixteen patients with DCM （DCM group） and 76 healthy subjects （control group） were examined by ultrasoundcardiogram.Left ventricular end-systolic diameter （LVESD）,left ventricular end-diastolic diameter （LVEDD）,left ventricular end-systolic volume （LVESV）,left ventricular end-diastolic volume （LVEDV）,left ventricular end-systolic volume index （LVESVI）,left ventficular end-diastolic volume index （LVEDVI）,left ventricular ejection fraction （LVEF） and EAT thickness were measured or calculated,and the relationship was evaluated.Results EAT thickness in DCM group was significantly lower than that in control group （4.7 ± 1.2） mm vs.（7.6 ± 2.1） mm],and there was statistical difference （P ＜ 0.05）.The linear correlation analysis results showed there was positive correlation between EAT thickness and LVESD,LVEDD,LVESV,LVEDV,LVEDVI,LVESVI （r =0.236,0.220,0.245,0.256,0.282,0.279,P ＜ 0.05）,and there was no relationship between EAT thickness and LVEF （r =0.134,P ＞0.05）.Conclusions In patients with DCM,there is a correlation between EAT thickness and ventricular remodeling.There is no correlation between EAT thickness and left ventricular dysfunction.