颈动脉内膜-中层厚度与无症状冠状动脉斑块的相关性研究

目的探讨无冠心病症状人群使用超声波评估颈动脉内膜．中层厚度（IMT）与冠状动脉cT造影（CTA）检出动脉粥样硬化斑块的相关l生。方法选择250例健康检查者作为研究对象，给予冠状动脉CTA筛查，根据检查结果分为未检出冠状动脉粥样硬化斑块180例（无斑块组）和检出冠状动脉粥样硬化斑块70例（斑块组）。同时采用高频超声波测量所有研究对象的颈动脉IMT。结果ANOVAs分析显示年龄与冠状动脉粥样硬化斑块形成显著相关（P〈0．05）。x2检验显示吸烟史、冠心病家族史与冠状动脉粥样硬化斑块形成显著相关（P〈0．05）。单变量Logistic回归分析显示颈动脉IMT、收缩压、舒张压、低密度脂蛋白胆固醇、空腹血糖、肌酐与冠状动脉粥样硬化斑块形成显著相关（P〈0．05）。将所有冠状动脉粥样硬化危险标记物带人多因素Logistic回归方程分析，结果显示颈动脉IMT与冠状动脉粥样硬化斑块形成呈独立相关性（P〈0．05）。结论无冠心病症状人群颈动脉IMT与冠状动脉CTA检出冠状动脉粥样硬化斑块显著相关。

The relationship between carotid intima-media thickness and coronary atherosclerosis plaque inasymptomatic individuals

Objective To investigate the relationship between carotid intima-media thickness（IMT） and coronary atherosclerosis plaque through coronary CT angiography （CTA） in asymptomatic individuals. Methods Two hundred and fifty cases with CTA screened were selected in asymptomatic individuals, and according to the inspection result they were divided into no plaque group （detection of no coronary atherosclerosis plaque, 180 cases） and plaque group （detection of coronary atherosclerosis plaque, 70 cases）. All cases were checked carotid IMT with B-ultrasonic. Results ANOVAs analysis showed that age and body mass index （BMI） had significant correlation with coronary atherosclerosis plaque （P 〈 0.05 ）. x2test was used to show the smoking and family history of coronary heart disease had significant correlation with coronary atherosclerosis plaque （P 〈 0.05 ）. Univariate Logistic regression analysis showed that carotid IMT, systolic pressure, diastolic pressure,low density lipoprotein cholesterol, fasting serum glucose and ereatinine had significant correlation with coronary atherosclerosis plaque （P 〈 0.05 ）. Muhifactor Logistic regression analysis showed that carotid IMT had correlation with coronary atherosclerosis plaque （P 〈 0.05 ）. Conclusion There is significant relationship between carotid IMT and coronary atherosclerosis plaque in asymptomatic individuals.