|
|||||
|
|
Experimental Oronasal Transmission of Chronic Wasting Disease Agent from White-Tailed Deer to Suffolk Sheep |
|
| Authors: | Eric D. Cassmann S. Jo Moore Justin J. Greenlee |
| Affiliation: | US Department of Agriculture, Ames, Iowa, USA |
| Abstract: | Chronic wasting disease (CWD) is a fatal prion disease of cervids. We examined host range of CWD by oronasally inoculating Suffolk sheep with brain homogenate from a CWD-positive white-tailed deer. Sixty months after inoculation, 1/7 sheep had immunoreactivity against the misfolded form of prion protein in lymphoid tissue. Results were confirmed by mouse bioassay. |
| Keywords: | chronic wasting disease CWD chronic wasting disease agent prions and related diseases transmissible spongiform encephalopathies animal diseases experimental oronasal transmission white-tailed deer Suffolk sheep zoonoses |