肥大细胞在肠易激综合征发病机制中的研究进展

肠易激综合征(irritable bowel syndrome,IBS)是以腹痛、腹部不适伴排便习惯改变和/或大便性状异常为特征的常见功能性胃肠病.IBS全球患病率为2%-15%.本病病因及发病机制尚不十分明确,目前认为多与胃肠动力异常、内脏高敏、感染与炎症、神经-内分泌失调、精神心理、食物过敏等多种因素有关.近年来提出的"神经-免疫-内分泌网络"理论在IBS发病机制中占有重要地位.研究发现,胃肠道的肥大细胞(mast cells,MCs)在IBS的发病中发挥着重要作用.本文拟以MCs在IBS中的发病机制的最新研究进展作一综述.

Progress in understanding the role of mast cells in the pathogenesis of irritable bowel syndrome

Irritable bowel syndrome(IBS) is a common functional gastrointestinal disorder characterized by abdominal pain/discomfort and changes in bowel habit.The global prevalence of IBS is 2%-15%.The etiology and pathogenesis of IBS are still unclear.It is currently believed that a variety of factors,such as abnormal gastrointestinal motility,visceral hypersensitivity,infection and inflammation,neuro-endocrine maladjustment,mental or psychological causes,and food allergy,may contribute to the development of IBS.The "neuro-immuno-endocrine network" hypothesis has been proposed in recent years to explain the pathogenesis of IBS.Mast cells in the digestive tract play an important role in the pathogenesis of IBS.In this article,we will review the recent advances in understanding the role of mast cells plays in the pathogenesis of IBS.