| 组织微环境对肿瘤发生发展的影响 |
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| 引用本文： | 孙凯,卫立辛,吴孟超.组织微环境对肿瘤发生发展的影响[J].第二军医大学学报,2008,29(10):1239-1243. |
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| 作者姓名： | 孙凯 卫立辛 吴孟超 |
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| 作者单位： | 第二军医大学东方肝胆外科医院肿瘤免疫与基因治疗中心,上海,200438 |
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| 基金项目： | 国家自然科学基金，上海市科委浦江人才计划，上海市"曙光计划" |
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| 摘 要： | 肿瘤微环境与肿瘤发生发展密切相关.最近的研究证实,肿瘤形成可能是干细胞分化异常导致.而微环境是干细胞稳态调节的关键,干细胞微环境的失调在肿瘤发生中扮演了重要角色.而在肿瘤发展过程中,适宜的微环境将促进肿瘤快速增殖,改变这些特异的微环境可以抑制肿瘤的恶性表型.同时.在肿瘤迁移过程中,微环境也起到了重要作用.这些机制的研究有助于加深对肿瘤的认识,为肿瘤的预防和治疗提供新的理论基础.
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| 关 键 词： | 微环境 肿瘤 干细胞 细胞增殖 |
| 收稿时间： | 2008/4/29 0:00:00 |
| 修稿时间： | 2008/6/30 0:00:00 |
The effect of tissue microenvironment on the initiation and development of cancer |
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| SUN Kai,WEI Li-xin,WU Meng-chao.The effect of tissue microenvironment on the initiation and development of cancer[J].Academic Journal of Second Military Medical University,2008,29(10):1239-1243. |
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| Authors: | SUN Kai WEI Li-xin WU Meng-chao |
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| Institution: | Tumor Immunology and Gene Therapy Center,Eastern Hepatobiliary Hospital,Second Military Medical University,Shanghai 200438,China |
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| Abstract: | Toumor microenvironment is closely related to the development and progression of tumors.Recently, researchers suggest that abnormal differentiation of stem cells might lead to the initiation of cancer.Microenvironment is the key to homeostatic regulation of stem cells.Disregulation of microenvironment plays an important role in the carcinogenesis.And during the development of tumor,a suitable microenvironment can promote the rapid proliferation of tumor.Changing the specific microenvironment can suppress the tumorigenic phenotype of aggressive cancer.Meanwhile,microenvironment also plays an essential role in cancer metastasis.Understanding of these underlying mechanisms will enhance our knowledge of cancer and will provide a novel basis for prevention and treatment of cancer.. |
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| Keywords: | microenvironment neoplasms stem cells cell proliferation |
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