羟基查尔酮类衍生物C8对东莨菪碱致痴呆小鼠学习记忆的影响

目的：观察羟基查尔酮类衍生物C8对东莨菪碱诱导的记忆障碍小鼠学习记忆的影响。方法：实验小鼠除空白对照组、东莨菪碱组（模型组）灌服0.5%CMC-Na溶液外,C8给药组（高、低2个剂量组）灌服C8,阳性对照组灌服吡拉西坦,连续灌胃22d。从第15天起进行Morris水迷宫试验,连续8d。结果：C8能明显缩短定位航行实验中模型小鼠的逃避潜伏期,明显延长空间探索实验中模型小鼠在原平台所在象限的游泳时间。结论：C8对东莨菪碱引起的小鼠学习记忆能力障碍有改善作用。

Effects of hydroxy chalcones derivative C8 on scopolamine-induced dementia of memory deficits in mice

Objective： To evaluate hydroxy chalcones derivative C8 on scopolamine-induced dementia learning and memory in mice. Methods： Excepted the blank control group and scopolamine hydrobromide group （oral 0.5%CMC-Na resolution）, C8 high-dose group and low-dose group were administered C8, positive control group was administered Piracetam for 22 days. The 15th day onwards, Morris water maze test was carried out for 8 days. Results： C8 could significantly shorten the escape latency of place navigation test in mice, prolonged the swim time of mice in the platform quadrant in spatial probe test. Conclusion： C8 has benefit to the injury of learning and memory function caused by scopolamine.