Stat3在寻常型银屑病患者皮损及其周围皮肤中的表达

Expression of Stat3 in the Lesions of Psoriasis vulgaris,Skin Tissues around the Lesions and Normal Skin Tissues

Objective ：To investigate the expression of Stat3 （ signal transducers and transcrip- tion activators 3） in the lesions of psoriasis vulgaris, skin tissues around the lesions and normal skin tissues. Methods：Detection of Stat3 was performed on the lesions and skin tissues 5 cm outside the lesions from 25 cases with psoriasis vulgaris as well as normal skin tissues from 25 normal controls using immunohistochemical SP method. Results：The Stat3 in the lesions of psoriasis vulgaffs was remarkably higher than that in normal skin （χ^2 =32.05, P 〈0.01 ） and skin tissues around skin lesions （ χ^2 = 17.01, P 〈 0. 01 ）. Conclusion ：The high level of Stat3 expresses in the lesions of psoriasis vulgaris,, it can promote cellular hyperplasia and hyperkeratosis and may play an important role in the pathogenesis of psoriasis vulgaffs.