益气活血中药对慢性心衰临床疗效及预后分析研究

目的:观察益气活血中药对慢性心衰气虚血瘀水停型患者的临床疗效及远期预后的影响。方法:选择80例慢性心衰属气虚血瘀水停型患者,随机分为治疗组和对照组,两组均给予基础西药治疗,治疗组在基础西药治疗的基础上加服益气活血中药颗粒剂,疗程1个月,随访9个月,治疗前后分别记录患者心衰疗效(Lee氏)记分、心功能分级(NYHA)、中医症状疗效积分、6 min步行试验、生活质量调查表评分、氢氯噻嗪片停减率、再住院率等指标。记录患者治疗前后血、尿常规、肝功能(AST、ALT)、肾功(CR、BUN)等指标。结果:治疗前后两组患者心功能分级、心衰疗效积分,均较前改善(P<0.05);中医症状疗效积分、6 min步行试验、生活质量调查表评分、氢氯噻嗪片停减率、再住院率较治疗前比较均明显改善,且治疗组优于对照组(P<0.05)。结论:益气活血中药可明显改善CHF患者心功能分级,提高心衰疗效,改善临床症状,增加患者运动耐量,提高生活质量,减少氢氯噻嗪使用量,降低其再住院率。

Clinical Curative Effect of Yiqi huoxue Herbs for Chronic Heart Failure and Analysis on Prognosis

Objective： To observe the clinical curative effect and long - term prognosis of the Yiqi Huoxue traditional Chinese medicine for chronic heart failure patients with qi deficiency blood stasis type. Methods ： 80 cases of chronic heart failure belonging to qi deficiency and blood stasis type patients were chosen and randomly divided into treatment group and control group. Two groups were given basic western medicine treatment. The treatment group on the basis of western medicine added Yiqi Huoxue granules. Treatment course was 1 month, followed up for 9 months. Before and after treatment, the curative effect in patients with heart failure （Lee＇s）score and grade of cardiac function （NYHA）, TCM symptoms curative effect of integral, 6 minutes walk test, the quality of life questionnaire scores, hydrochlorothiazide tablet indicators reduction rate and hospitalization rates were respec- tively recorded. Before and after treatment, patients/blood and urine routine, liver function（ AST, ALT）and renal function（ such as CR, BUN）were observed. Results：After treatment, two groups cardiac function grading and the curative effect of integral were sig- nificantly improved（P 〈0. 05）. TCM symptoms curative effect of integral,6 minutes walk test,the quality of life questionnaire scores,hydrochlorothiazide tablet stopped reduction rate, and hospitalization rates were significantly improved than those before treatment, and the treatment group was better than that of control group （ P 〈 0. 05 ）. Conclusion ： Yiqi Huoxue granules of tradition- al Chinese medicine can obviously improve cardiac function in patients with CHF,improve the curative effect of heart failure,im- prove the clinical symptoms, increase exercise tolerance, improve the quality of life, reduce hydrochlorothiazide use, and reduce the hospitalization rates again.