泮托拉唑与奥美拉唑对消化性溃疡致上消化道出血的疗效比较

目的:比较泮托拉唑与奥美拉唑对消化性溃疡致上消化道出血的疗效和安全性.方法:选择中南大学湘雅二医院2003年9月～2004年3月间收治的消化性溃疡致上消化道出血患者138例,进行回顾性调查分析,详细记录患者呕血、黑便的时间和数量,血压、脉搏、腹痛和肠鸣音的变化,以及药物不良反应等情况.结果:治疗后3 d内泮托拉唑组(96例)有83例止血(86.46%),奥美拉唑组(42例)有33例止血(78.57%);4～5 d内两组止血病例分别为11例和7例;两组总有效率分别为97.92%和95.24%.治疗中均未见明显药物不良反应.结论:泮托拉唑与奥美拉唑针剂对消化性溃疡出血的治疗均安全有效.

The Comparison of the Efficacy Between Pantoprazole and Omeprazole in the Treatment of Peptic- ulcer- induced Upper Gastrointestinal Hemorrhage

Objective:To compare the efficacy and the safety between pantoprazole and omeprazole in the treatment of peptic-ulcer-induced upper gastrointestinal hemorrhage.Methods:The authors reviewed 138 patients with peptic-ulcer-induced upper gastrointestinal hemorrhage(Sep,2003-Mar,2004).Ninety six patients(treatment group) were treated by pantoprazole,and 42 patients(control group) by omeprazole. Registered the time and the amount of hematemesis and hematochezia,registered blood pressure,pulse,bellyache,change of gurgling sound and adverse reactions.Results:The results showed that 83 patients in treatment group(86.46%) were stanched within 3 days,and 33 patients in control group (78.57%) were done.The numbers of patients were stanched between 4 and 5 days were eleven(11.46%) and seven(16.67%).The total effective rates were 97.92% and 95.24%.There were not significantly adverse reactions in two groups.Conclusion:Pantoprazole and omeprazole both were an effective and safe in the treatment of peptic-ulcer-induced upper gastrointestinal hemorrhage.