内镜微创保胆取石术与腹腔镜胆囊切除术的可行性与有效性比较的Meta分析

目的用Meta分析方法比较评价内镜微创保胆取石术(EMIC)与腹腔镜胆囊切除术(LC)的可行性及有效性。方法利用计算机MEDLINE(PubMed)、OVID、中国知网全文数据库(CNKI)、万方数据库全面搜索内镜微创保胆取石与腹腔镜胆囊切除术的可行性及有效性的比较研究的中英文随机对照试验和回顾性分析文献,利用Rev Man 5.1软件对2种治疗方法的可行性和有效性指标进行Meta分析。结果最终纳入13篇文献共2 441例患者,其中随机对照研究4篇,回顾性分析9篇。内镜微创保胆取石术与腹腔镜胆囊切除术相比,内镜微创保胆取石的术中出血量减少,术后排气时间、术后住院时间缩短,术后并发症及消化道症状发生率降低;2种方法手术时间则无统计学意义。结论内镜微创保胆取石术的可行性和有效性均优于腹腔镜胆囊切除术。

Meta-analysis of feasibility and safety of endoscopic minimally invasive cholecystolithotomy and laparoscopic cholecystectomy

Objective It is to evaluate the feasibility and safety of endoscopic minimally invasive cholecystolithotomy(EMIC) and laparoscopic cholecystectomy(LC).Methods A comprehensive literature search of MEDLINE(PubMed),OVID,CNKI,Wanfang Databases were performed for all English or Chinese randomized controlled trial or retrospective studies comparing the feasibility and safety of EMIC with LC.A meta-analysis was carried out by RevMan5.1 software on the outcomes concerning feasibility and safety of the two groups.Results Thirteen studies matched the criteria including 2441 patients,in which there were four randomized controlled trials and nine retrospective analysis.Compared with the LC group,the EMIC group had a less amount of bleeding in operation,shorter interval to first flatus and shorter length of hospitalization stay,lower complications and gastrointestinal symptoms.There was no significant differences between the two groups in operation time.Conclusion The feasibility and safety of EMIC is superior to LC.