黄芩汤加减滴鼻剂对变应性鼻炎豚鼠模型血清IL-4和IL-5的影响

目的研究黄芩汤加减滴鼻剂对变应性鼻炎豚鼠模型血清IL-4和IL-5的影响。方法用卵白蛋白(OVA)造成变应性鼻炎豚鼠模型,随机分为空白组、模型组、西药组和中药滴鼻剂高、中、低频率组6组,连续给药4周后处死,抽取腹主动脉血,离心后测量血清中IL-4和IL-5含量。结果与模型组比较,西药组与黄芩汤滴鼻剂高、中、低频率组血清中IL-4水平极显著性下降(P<0.001),IL-5水平显著降低(P<0.01)。结论黄芩汤滴鼻剂能极显著降低变应性鼻炎血清中IL-4和IL-5水平,从而对变应性鼻炎起到治疗作用。

Effect of Huangqin Decoction naristillae on IL-4 and IL-5 in serum of allergic rhinitis guinea pig models

Objective It is to observe the influence of Huangqin Decoction naristillae on IL-4 and IL-5 in serum of allergic rhinitis guinea pig models.Methods The guinea pig models of allergic rhinitis were obtained by OVA injection and inhalation,and were divided into 6 groups randomly: blank group,model group,western medicine group,Huangqin Decoction low frequency,middle frequency and high frequency group.After 4 weeks administration,all the guinea pigs were executed.The levels of IL-4 and IL-5 of serum in aorta were measured by Elisa.Results In comparison with model group,IL-4 of serum in western medicine group,Huangqin Decoction low frequency,middle frequency and high frequency group were decreased very significantly(P < 0.001),as well as IL-5(P < 0.01).Conclusion Huangqin Decocion naristillae can markedly decrease the levels of IL-4 and IL-5 of serum and so to cure allergic rhinitis.