鼻渊舒治疗鼻窦炎和鼻息肉及其对睡眠结构的影响

目的观察鼻渊舒对慢性鼻窦炎和鼻息肉患者治疗的临床疗效及对睡眠结构影响。方法慢性鼻窦炎和鼻息肉患者72例,随机分为对照组和观察组各36例。其中对照组常规给予抗生素、类固醇激素类药物治疗;观察组给予鼻渊舒治疗。治疗2周后对患者临床疗效进行检测,6个月后对患者进行多导睡眠检测,分析睡眠结构。结果对照组治疗后痊愈4例,显效11例,好转13例,无效8例,总有效率78%;治疗组治疗后痊愈5例,显效13例,好转15例,无效8例,总有效率92%。2组疗效相比较有显著性差异(P<0.05)。2组非快速眼动睡眠各期、快速眼动(REM)睡眠、微觉醒指数、呼吸暂停通气指数(AHI)和体质量指数等指标治疗前后比较均有显著性差异(P均<0.05);治疗后AHI和微觉醒指数2组比较有显著性差异(P均<0.05)。6个月后复查,2组的总觉醒指数、AHI均低于手术前水平(P均<0.05),对照组中Sl期睡眠检测值降低,S2期睡眠检测值相应升高(P<0.05);观察组S3—4期睡眠和快速眼动睡眠检测值显著增高(P均<0.05)。结论鼻渊舒对慢性鼻窦炎和鼻息肉患者临床疗效及睡眠结构均有较好的改善作用,值得临床广泛应用。

Effect of Nasosinusitis Relieving on sinusitis and nasal polyp and its influence on sleep structure

Objective It is to observe the therapeutic effect of Nasosinusitis Relieving on chronic sinusitis and nasal polyps and the influence on sleep structure.Methods 72 patients with chronic sinusitis and nasal polyp endoscopic were divided into control group and observation group with 36 cases in each group.The patients were treated with antibiotics and steroid hormones in conventional medicine in control group and Nasosinusitis Relieving in observation group.The clinical efficacy was evaluated after treatment for 2-week,and sleep structure was analyzed by polysomnography testing after 6-month.Results After treatment,4 cases were curative,11 cases were excellent improved,13 cases were improved,8 cases were invalid in control group,the total efficiency was 78%;and the data was 5 cases,13 cases,15 cases,8 cases and 92% respectively in observation group.There was significant differences between the both groups(P<0.05);there were significant differences before and after treatment in polysomnographic indexes of two groups(all P<0.05);there were significant differences between two groups in general arousal index and AHI(all P<0.05).After followed up for 6-month,the general arousal index and AHI were lower than those before operation(all P<0.05);the values was decreased in S1 period and was elevated in S2 period;The value of S3—4 and rapid eye movement sleep were markedly elevated in observation group(all P<0.05).Conclusion Nasosinusitis Relieving can improve the clinical curative effect and sleep structure in treatment of patients with chronic sinusitis and nasal polyps,it is worthy to clinical application.