| Enalapril对实验性糖尿病大鼠肾脏的保护作用机理研究 |
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| 引用本文： | 傅静奕 田浩明 等. Enalapril对实验性糖尿病大鼠肾脏的保护作用机理研究[J]. 华西医科大学学报, 2001, 32(1): 80-82 |
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| 作者姓名： | 傅静奕 田浩明 等 |
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| 摘 要： | 目的 研究血管紧张素转换酶抑制剂Enalapril对糖尿病的肾病治疗作用机理，方法 以Enalapril治疗实验性糖尿病大鼠，并将正常组、糖尿病对照组及治疗组尿蛋白水平及肾组织转化生长因子β-糖基化终末产物含量进行比较，结果 Enalapril治疗组大鼠肾组织转化生长因子β及糖基化终末产物含量与糖尿病对照组相比无下降。结论 Enalapril的肾脏保护作用并非通过抑制肾组织转化生长因子β上调或糖基化终末产物积聚。
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| 关 键 词： | 糖尿病肾病 ENALAPRIL 转化生长因子－β 糖基化终末产物 血管紧张素转化酶抑制剂 |
The mechanism of protective effects of enalapril on experimental diabetic nephropathy of rats] |
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| J Fu,H Tian,J Liang. The mechanism of protective effects of enalapril on experimental diabetic nephropathy of rats][J]. Journal of West China University of Medical Sciences, 2001, 32(1): 80-82 |
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| Authors: | J Fu H Tian J Liang |
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| Affiliation: | Department of Endocrinology, First Affiliated Hospital, WCUMS, Chengdu 610041, China. |
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| Abstract: | OBJECTIVE: To elucidate the mechanisms of renoprotective effects of ACEI on diabetic animals and patients. METHODS: STZ-induced diabetic rats were treated with Enalapril and the levels of urine protein, TGF-beta and AGEs in renal tissue were measured and compared. RESULTS: The results of TGF-beta quantitation and AGE fluorescence of Enalapril treatment group rats were the same as those of diabetic control rats. CONCLUSION: Suppression of TGF-beta overexpression or AGEs accumulation was not implicated in the mechanisms of renoprotective effects of ACEI. |
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