乌司他丁联合奥曲肽治疗重症急性胰腺炎的效果观察

目的探讨乌司他丁联合醋酸奥曲肽治疗重症急性胰腺炎（SAP）的临床效果。方法将146例SAP患者按随机数字表法分为两组,每组各73例。对照组给予醋酸奥曲肽治疗,观察组在对照组的基础上加用乌司他丁治疗。比较两组的效果。结果观察组的总有效率为95.89%,明显高于对照组的83.56%（χ2=4.6953,P〈0.05）;观察组治疗后的CRP、TNF-α、IL-6、IL-10等血清炎症因子水平均较对照组明显下降（P均〈0.05）,胃肠减压、血淀粉酶恢复正常、腹痛消除、住院时间均短于对照组（P均〈0.05）,满意度为97.26%,明显高于对照组的84.93%（P〈0.05）。结论乌司他丁联合奥曲肽治疗SAP的效果肯定,两者具有很好的协同作用,可明显降低血清炎症因子水平,显著缩短住院时间,预后良好。

Effect observation of ulinastatin combined with octreotide treating severe acute pancreatitis

Objective To investigate the effect of ulinastatin combined with octreotide acetate treating severe acute pancreatitis（SAP）. Methods 146 patients with SAP were divided into the two groups according to the random number table method,and there were 73 cases in each group.The control group was given octreotide acetate,the observation group was given ulinastatin on the basis of the control group.The effect of the two groups were compared. Results The total effective rate in the observation group（95.89%） was significantly higher than that in control group（83.56%0（χ^2=4.6953,P〈0.05）;serum inflammatory factors（CRP,TNF- α,IL-6,IL-10）level in the observation group after treatment were decreased significantly compared with the control group（all P〈0.05）,the time of gastrointestinal decompression,blood amylase returning to normal,abdominal pain eliminated,hospitalization in the observation group were shorter than those in the control group（all P〈0.05）,and the satisfaction degree in the observation group（97.26%） was higher than that in the control group（84.93%）（P〈0.05）. Conclusion The effect of ulinastatin combined with octreotide treating SAP is definite with the very good synergy,and it can significantly reduced the level of serum inflammatory factors,significantly shorten the time of hospitalization,the prognosis is good.