| GLP体制下细菌回复突变试验的实施 |
| |
| 引用本文： | 胡燕平,宋 捷,张 旻,王秀文,李 波.GLP体制下细菌回复突变试验的实施[J].中国新药杂志,2009,18(2):102-104. |
| |
| 作者姓名： | 胡燕平 宋 捷 张 旻 王秀文 李 波 |
| |
| 作者单位： | 中国药品生物制品检定所国家药物安全评价监测中心，北京100176 |
| |
| 摘 要： | 细菌回复突变试验(Bacterial Reverse Mutation Test，Ames Test)作为化学品及药物遗传毒初筛的经典方法，已在致突变研究中应用了30多年，但在试验操作程序和规范方面仍存在一些问题。文中将在GLP(Good Laboratory Practice)体制下实施细菌回复突变试验的做法进行总结，以确保获取完整、真实、可靠的研究数据。
|
| 关 键 词： | GLP体制 细菌回复突变试验 规范 |
Performance of bacterial reverse mutation test in GLP system |
| |
| HU Yan-ping,SONG Jie,ZHANG Min,WANG Xiu-wen,LI Bo.Performance of bacterial reverse mutation test in GLP system[J].Chinese Journal of New Drugs,2009,18(2):102-104. |
| |
| Authors: | HU Yan-ping SONG Jie ZHANG Min WANG Xiu-wen LI Bo |
| |
| Abstract: | Bacterial reverse mutation test is the classical method for screening of potential mutagens and carcinogens of drugs and chemicals. Although Ames test has been used for more than 30 years, there are still many problems in the operation and conformance with the GLP standards. Operation and the experiences of Ames test under GLP system are summarized in this article to ensure the data obtained from study complete, real and reliable. |
| |
| Keywords: | GLP system bacterial reverse mutation test standard requirement |
|
| 点击此处可从《中国新药杂志》浏览原始摘要信息 |
