盐酸氨溴索注射液治疗慢性支气管炎急性发作80例临床疗效观察

目的观察盐酸氨溴索注射液治疗慢性支气管炎急性发作的临床疗效。方法该组80例为解放军第537医院2006年10月—2008年12月收治的慢性支气管炎急性发作期患者,随机分为治疗组和对照组各40例。对照组给予抗感染、祛痰镇咳、解痉平喘等常规治疗,治疗组在常规治疗基础上加用盐酸氨溴索注射液30mg＋5%葡萄糖（或生理盐水）注射液250ml静脉滴注,2次/d,疗程7～10d。观察咳嗽、咳痰情况,肺部啰音变化情况,体温恢复情况等。结果治疗组显效11例（27.50%）,有效26例（65.00%）,无效3例（7.50%）,总有效率92.50%;对照组显效7例（17.50%）,有效23例（57.50%）,无效10例（25.00%）。两组疗效比较,差异有统计学意认（P〈0.05）。两组治疗期间均未出现明显不良反应,临床用药安全。结论在常规抗感染、祛痰镇咳、解痉平喘基础上加用盐酸氨溴索注射液治疗慢性支气管炎急性发作临床疗效确切,且用药安全性好,值得临床推广应用。

Observation on Clinical Efficacy of Ambroxol Hydrochloride Injection on 80 Cases of Acute Attack of Chronic Bronchitis

[Objectives]To observe the clinical efficacy of ambroxol hydrochloride injection on acute attack of chronic bronchitis.[Methods]80 patients with acute attack of chronic bronchitis in No. 537 Hospital of PLA from October 2006 to December 2008 were randomly divided into the control group （40 cases） and the treatment group （40 cases）. The control group was given the conventional treatment which included anti-infection, expectorant and antiasthmatic. On the basis of conventional therapy, the treatment group received additional ambroxol hydrochloride injection 30 mg ＋ 5% glucose （or normal saline） injection 250 ml by intravenous drip, twice a day for 7~14 days. The incidence of cough and expectoration, change of lung rale, and recovery of body temperature were observed.[Results]In the treatment group, there were 11 cases with marked effect （27.50%）, 16 cases showed effect （65.00%）, 3 cases were no effect （7.50%）, and the total effective rate was 92.50%. In the control group, there were 7 cases with marked effect （17.50%）, 23 cases showed effect （57.50%）, 10 cases were no effect （25.00%）. There was significant difference between two groups （P0.05）. No adverse reaction was found in two groups during the treatment period, the clinical medication was safe.[Conclusion]On the basis of conventional therapy of anti-infection, expectorant and antiasthmatic, additional ambroxol hydrochloride injection has definite therapeutic effect and good safety on acute attack of chronic bronchitis, is worth popularizing and applying in clinic.