| Dual effects of 5-hydroxytryptamine on stable analogue of thromboxane A~(2~_) induced aggregation and release reaction in rabbit platelets |
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| 引用本文： | 李柏岩,周有财,李文汉. Dual effects of 5-hydroxytryptamine on stable analogue of thromboxane A~(2~_) induced aggregation and release reaction in rabbit platelets[J]. Acta pharmacologica Sinica, 1998, 0(2) |
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| 作者姓名： | 李柏岩 周有财 李文汉 |
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| 作者单位： | 哈尔滨医科大学药理教研室 |
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| 摘 要： | 目的：研究５ＨＴ对ＳＴＡ２血小板聚集和释放反应的影响及可能的分子机制．方法：以透光法，介质中ＡＴＰ含量及荧光图像法评价血小板变形，聚集反应和［Ｃａ２］ｉ水平．结果：（１）５ＨＴ预处理可消除ＳＴＡ２的血小板变形，ＳＴＡ２０３μｍｏｌ·Ｌ－１的聚集增强，ｌ－３μｍｏｌ·Ｌ－１的聚集不变，释放反应抑制．（２）５ＨＴ预处理增加ＳＴＡ２０３μｍｏｌ·Ｌ－１的［Ｃａ２＋］ｉ，降低３μｍｏｌ·Ｌ－１的［Ｃａ２＋］ｉ降低．（３）延长加入５ＨＴ和ＳＴＡ２的间隔，ＳＴＡ２０３μｍｏｌ·Ｌ－１的聚集增强，３μｍｏｌ·Ｌ－１的聚集不变，释放反应抑制．结论：５ＨＴ对ＳＴＡ２介导的聚集和释放反应有双重影响．对ＳＴＡ２［Ｃａ２＋］ｉ的调节可能是上述反应的分子机制．
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| 关 键 词： | 血小板聚集；腺苷三磷酸；钙；血清素；血栓素A_2 |
Dual effects of 5 hydroxytryptamine on stable analogue of thromboxane A 2 induced aggregation and release reaction in rabbit platelets |
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| LI Bai Yan ,ZHOU You Cai,LI Wen Han. Dual effects of 5 hydroxytryptamine on stable analogue of thromboxane A 2 induced aggregation and release reaction in rabbit platelets[J]. Acta pharmacologica Sinica, 1998, 0(2) |
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| Authors: | LI Bai Yan ZHOU You Cai LI Wen Han |
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| Affiliation: | LI Bai Yan 2,ZHOU You Cai,LI Wen Han |
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| Abstract: | |
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| Keywords: | platelet aggregation adenosine triphosphate calcium serotonin thromboxane A 2 |
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