| 莪术醇对人胃癌SGC-7901细胞增殖和凋亡的影响 |
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| 引用本文： | 杨甲平,齐宝宁. 莪术醇对人胃癌SGC-7901细胞增殖和凋亡的影响[J]. 陕西中医学院学报, 2009, 32(6): 69-71 |
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| 作者姓名： | 杨甲平 齐宝宁 |
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| 作者单位： | 1. 陕西省安康市汉滨区第二人民医院内科,陕西,安康,725021
2. 陕西中医学院公共卫生系,陕西,咸阳,712046 |
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| 摘 要： | 目的研究莪术醇对人胃癌SGC-7901细胞生物学特性的影响。方法用MTT法测定莪术醇对SGC-7901细胞增殖的影响，流式细胞仪检测莪术醇对SGC7—901细胞周期和细胞凋亡的影响。结果10、30、100μg／mL莪术醇均能够抑制胃癌SGC-7901细胞的增殖；莪术醇能使S和G2／M期肿瘤细胞比例减少，G0／G1期肿瘤细胞比例增加，其中100μg／mL浓度的莪术醇作用最强（F=88．14，P〈0．01）；莪术醇诱导肿瘤细胞凋亡，其中100μg/mL浓度的莪术醇凋亡作用最强（F=34．14，P〈0．01）。结论莪术醇诱导肿瘤细胞凋亡，抑制肿瘤细胞的增殖，
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| 关 键 词： | 莪术醇 细胞增殖 细胞周期 细胞凋亡 |
The Effects of Curcumol on Multiplication and Apoptosis of Gastric Cancer SGC-7901 Cells |
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| Yang Jiaping,Qi Baoning. The Effects of Curcumol on Multiplication and Apoptosis of Gastric Cancer SGC-7901 Cells[J]. Journal of Shaanxi College of Traditional Chinese Medicine, 2009, 32(6): 69-71 |
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| Authors: | Yang Jiaping Qi Baoning |
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| Affiliation: | Yang Jiaping, Qi Baoning ( 1. Internal Medicine Department of the Second People＇s Hospital of Hanbin District, Ankang, Shaanxi Province, 725021 ; 2. Department of Public Health, Shaanxi University of Chinese Medicine, Xanyang, Shaanxi, 712046) |
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| Abstract: | Objective To investigate the effects of curcumol on the biological property of gastric cancer SGC -7901 cells. Methods MTF was used to test the effects of curcumol on the multiplication of SGC -7901 cells, and flow cytometer was applied to test the effects of curcumol on the cell cycle and apoptosis of SGC -7901 cells. Results： 10, 30 and 100μg/ mL curcumol could all inhibit the multiplication of gastric cancer SGC - 7901 cells. Curcumol could reduce the amount of S and G2/M stage cancer cells, and increase the amount of cancer cells in stage G0/G1. 100μg/mL curcumol was the most effective （ F = 88.14 ,P 〈0.01 ）. Curcumol could induce cell apoptosis, and 100μg/mL curcumol was the most effective （ F = 34.14,P 〈0.01 ）. Conclusion Curcumol can induce the apeptosis and inhibit the multiplication of cancee cells |
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| Keywords: | curcumol cell multiplication cell cycle cell apoptosis |
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