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A comparison of serum antivenom concentrations after intravenous and intramuscular administration of redback (widow) spider antivenom |
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| Authors: | Isbister Geoffrey K O'Leary Margaret Miller Mark Brown Simon G A Ramasamy Sharmaine James Rosemary Schneider Jennifer S |
| Institution: | Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin,;Department of Clinical Toxicology and Pharmacology, Newcastle Mater Hospital, Newcastle,;Faculty of Health, University of Newcastle, Newcastle,;Emergency Department, John Hunter Hospital, Hunter Area Health Service, Newcastle,;Discipline of Emergency Medicine, The University of Western Australia and Emergency Department, Fremantle Hospital, Perth,;Defence Science and Technology Organization, Human Protection and Performance Division, 506 Lorimer Street, Fishermans Bend, Victoria and;Pharmacy Department, Newcastle Mater Hospital, Newcastle, Australia |
| Abstract: | WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT ? Widow spider antivenoms, including redback spider antivenom, are often given by the intramuscular route. ? No studies have measured widow spider antivenom following intramuscular or intravenous antivenom. WHAT THIS STUDY ADDS ? Intramuscular redback spider antivenom is not detectable in serum for at least 3–5 h after treatment. Intravenous antivenom is detectable 30 min after intravenous infusion. ? Intramuscular antivenom may not be an effective administration route. AIMS There are no studies measuring antivenom concentrations following intramuscular administration. This study aimed to compare antivenom concentrations following intravenous and intramuscular administration of redback spider antivenom (RBSAV). METHODS Twenty patients recruited to a controlled trial comparing intramuscular and intravenous administration of antivenom had serial blood samples collected at 30 min intervals for 2 h after the administration of one or two doses of antivenom. Antivenom concentration was measured using an enzyme immunoassay. RESULTS Ten patients received intramuscular antivenom but antivenom could not be detected in serum after either one or two vials, at any time point. The median time of the final sample after commencement of antivenom treatment in these patients was 3.2 h (1.8–5 h). Ten patients received intravenous antivenom (three one vial and seven two or more vials) and antivenom was detected in all patients. CONCLUSIONS RBS AV given by the intramuscular route is unlikely to be effective in the treatment of redback (widow) spider bite. |
| Keywords: | antivenom widow spider arachnidism intramuscular administration Latrodectus envenoming |
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