Serotonin transporter binding after recovery from eating disorders |
| |
| Authors: | Ursula F. Bailer Guido K. Frank Shannan E. Henry Julie C. Price Carolyn C. Meltzer Carl Becker Scott K. Ziolko Chester A. Mathis Angela Wagner Nicole C. Barbarich-Marsteller Karen Putnam Walter H. Kaye |
| |
| Affiliation: | (1) Western Psychiatric Institute and Clinic, University of Pittsburgh, Iroquois Building, Suite 600, 3811 O’Hara Street, Pittsburgh, PA 15213, USA;(2) Psychiatry, University of California San Diego, 8950 Villa La Jolla Drive, Suite C207, La Jolla, CA 92037, USA;(3) Department of Biological Psychiatry, University Hospital of Psychiatry, Medical University of Vienna, Vienna, Austria;(4) Department of Radiology, Presbyterian University Hospital, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA;(5) Departments of Radiology and Neurology, Emory School of Medicine, Atlanta, GA, USA;(6) School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA;(7) Laboratory for Developmental Brain Research, University of Colorado at Denver and Health Sciences Center, The Children’s Hospital, 1056 E. 19th Avenue, Denver, CO 80218, USA;(8) Department of Child and Adolescent Psychiatry, J.W. Goethe University of Frankfurt/Main, Frankfurt/Main, Germany;(9) New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA;(10) Department of Environmental Health, Division of Epidemiology and Biostatistics, University of Cincinnati School of Medicine, Cincinnati, OH, USA |
| |
| Abstract: | RATIONALE: Several lines of evidence suggest that altered serotonin (5-HT) function persists after recovery from anorexia nervosa (AN) and bulimia nervosa (BN). OBJECTIVES: We compared 11 subjects who recovered (>1 year normal weight, regular menstrual cycles, no binging or purging) from restricting-type AN (REC RAN), 7 who recovered from bulimia-type AN (REC BAN), 9 who recovered from BN (REC BN), and 10 healthy control women (CW). MATERIALS AND METHODS: Positron emission tomography (PET) imaging with [11C]McN5652 was used to assess the 5-HT transporter (5-HTT). For [11C]McN5652, distribution volume (DV) values were determined using a two-compartment, three-parameter tracer kinetic model, and specific binding was assessed using the binding potential (BP, BP=DVregion of interest/DVcerebellum-1). RESULTS: After correction for multiple comparisons, the four groups showed significant (p<0.05) differences for [11C]McN5652 BP values for the dorsal raphe and antero-ventral striatum (AVS). Post-hoc analysis revealed that REC RAN had significantly increased [11C]McN5652 BP compared to REC BAN in these regions. CONCLUSIONS: Divergent 5-HTT activity in subtypes of eating disorder subjects may provide important insights as to why these groups have differences in affective regulation and impulse control. |
| |
| Keywords: | Anorexia nervosa Bulimia nervosa Serotonin transporter Positron emission tomography Serotonin 5-HTTLPR |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
