Flavonoid glycosides from the stem bark of Margaritaria discoidea demonstrate antibacterial and free radical scavenging activities |
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| Authors: | Edmund Ekuadzi Rita Dickson Theophilus Fleischer Kofi Annan Dominik Pistorius Lukas Oberer Simon Gibbons |
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| Affiliation: | 1. Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, , Kumasi, Ghana;2. Department of Herbal Medicine, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, , Kumasi, Ghana;3. Natural Product Unit, Novartis Institutes for Biomedical Research, , Basel, 4056 Switzerland;4. Analytical Sciences, Novartis Institutes for BioMedical Research, , Basel, 4056 Switzerland;5. Department of Biological and Pharmaceutical Chemistry, UCL School of Pharmacy, , London, WC1N 1AX UK |
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| Abstract: | One new flavonoid glycoside, along with three known flavonoid glycosides were isolated from the stem bark of Margaritaria discoidea, which is traditionally used in the management of wounds and skin infections in Ghana. The new flavonoid glycoside was elucidated as hydroxygenkwanin‐8‐C‐[α‐rhamnopyranosyl‐(1 → 6)]‐β‐glucopyranoside (1) on the basis of spectroscopic analysis. The isolated compounds demonstrated free‐radical scavenging as well as some level of antibacterial activities. Microorganisms including Staphylococcus aureus are implicated in inhibiting or delaying wound healing. Therefore, any agent capable of reducing or eliminating the microbial load present in a wound as well as decreasing the levels of reactive oxygen species may facilitate the healing process. These findings therefore provide some support to the ethnopharmacological usage of the plant in the management of wounds. Copyright © 2013 John Wiley & Sons, Ltd. |
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| Keywords: | Margaritaria discoidea flavonoid glycosides margadiscoside fagovatin antibacterial activities antioxidant activities |
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