Effect of Crocus sativus L. (Saffron) on Coagulation and Anticoagulation Systems in Healthy Volunteers |
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Authors: | Hossein Ayatollahi Atefeh Ordoei Javan Mohammad Khajedaluee Masood Shahroodian Hossein Hosseinzadeh |
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Affiliation: | 1. Cancer Molecular Pathology Research Center, Department of Hematopathology and Blood Banking, Faculty of Medicine, Mashhad University of Medical Sciences, , Mashhad, Iran;2. Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, , IR, Iran;3. Department of Social Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, , IR, Iran;4. Sarvar Specialized Polyclinic Lab, , Mashhad, IR, Iran;5. Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, , Mashhad, I.R, Iran |
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Abstract: | Saffron showed some effects on blood coagulation and platelet aggregation in in vitro and in vivo studies. In a clinical trial with a limited number volunteers, saffron tablets influenced on bleeding time. In this study, the effect of saffron on plasma level of fibrinogen, factor VII (as coagulant agent), C and S protein (as anti‐coagulant agent), PT and PTT in a larger sample size was evaluated. The study was a double‐blind, placebo‐controlled study consisting of 1 week treatment with 200 mg and 400 mg saffron tablets. Sixty healthy volunteers (age range 20–50 years) were selected for the study. The volunteers were divided into three groups of 20 each. Group 1 received placebo; Groups 2 and 3 received 200 mg and 400 mg saffron tablets, respectively, for 7 days (1 tablet per day). Before and after 7 days treatment and also 1 month after that, blood samples were taken. The plasma levels of fibrinogen, factor VII, C and S protein, PT and PTT were evaluated. Statistical analysis showed no difference between groups for any of evaluated factors. This study rejected any effect of saffron with dose of 200 and 400 mg for 1 week on coagulant and anticoagulant system. Copyright © 2013 John Wiley & Sons, Ltd. |
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Keywords: | Crocus sativus saffron clinical trial coagulation anticoagulant platelet aggregation |
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