Hungarian mtDNA population databases from Budapest and the Baranya county Roma |
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Authors: | Jodi Irwin Balazs Egyed Jessica Saunier Gabriella Szamosi Jennifer O’Callaghan Zsolt Padar Thomas J Parsons |
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Institution: | (1) Armed Forces DNA Identification Laboratory, Armed Forces Institute of Pathology Building 101, 1413 Reseach Boulevard, Rockville, MD 20850, USA;(2) Department of HaemoGenetics, Institute for Forensic Sciences, 1903 Budapest POB. 314/4, Hungary;(3) Present address: International Commission on Missing Persons, Alipašina 45 A, 71000 Sarajevo, Bosnia and Herzogovina |
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Abstract: | To facilitate forensic mtDNA testing in Hungary, we have generated control region databases for two Hungarian populations:
211 individuals were sampled from the urban Budapest population and 208 individuals were sampled from a Romani (“gypsy”) population
in Baranya county. Sequences were generated using a highly redundant approach to minimize potential database errors. The Budapest
population had high sequence diversity with 180 lineages, 183 polymorphic positions, and a random match probability of 1%.
In contrast, the Romani population exhibited low sequence diversity, with only 56 lineages, 109 segregating sites, and a random
match probability of 8.8%. The mtDNA haplogroup compositions of the two populations were also distinct, with the large proportion
of haplogroup M samples (35%) in the Roma the most obvious difference between the two populations. These factors highlight
the importance of considering population structure when generating reference databases for forensic testing purposes. Comparisons
between our Romani population sample and other published data indicate the need for heightened caution when sampling and using
mtDNA databases of small endogamous populations. The Romani populations that we compared showed significant departures from
genetic uniformity.
Electronic supplementary material Supplementary material is available in the online version of this article at and is accessible for authorized users. |
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Keywords: | mtDNA Baranya county Romani population |
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