氟西汀对产后抑郁患者血浆NPY含量的影响

目的探讨氟西汀对产后抑郁患者血浆神经肽Y（NPY）含量的影响及其对抑郁障碍的改善作用。方法采用放免法测定60倒产后抑郁患者治疗前后血浆NPY水平并评定治疗后抑郁症的改善情况。结果氟西汀治疗组抑郁好转或痊愈23例，安慰剂治疗组抑郁好转6例。氟西汀组治疗后的血浆NPY水平高于对照组（P〈0.01）。结论氟西汀能改变产后抑郁患者血浆NPY水平，有明显改善抑郁作用。

Effect of fluoxetine on plasm neuropeptide in patients with postpartum depression

[Objective] To explore the effect of Fluoxetine on neuropeptide Y(NPY) content in plasma and depressive symptom in patients with Postpartum deperession. [Methods] Radioimmunoassay technique was used for the measurement of plasma NPY level in sixty patients with postpartum depression at pre- and post-treatment. HAMD scale was used for the evaluation of depression condition in these patients at pre- and post-treatment. [Results] The depressive condition in 23 patients in Fluoxetine group were improved or cured, while 6 patients in control group were improved. The level of plasm neuropeptide in Fluoxetine group after treatment was significant higher than in control group(P <0.001). [Conclusion] Fluoxetine can increase the plasma NPY level in patient with depression, and improve deprssive symptoms.