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Radiotherapy in the treatment of low-grade astrocytomas
Authors:Richard D Chadderton  Charles G H West  Stephan Schulz  D Christopher Quirke  Rao Gattamaneni  Robert Taylor
Institution:(1) Department of Neurological Surgery, Royal Manchester Children's Hospital, M27 1HA Manchester, UK;(2) Christie Hospital, M20 9BX Manchester, UK;(3) Holt Radium Institute, M20 9BX Manchester, UK
Abstract:Between 1954 and 1986 inclusive, 160 children in the North West Region of England were registered with histologically proven lowgrade astrocytomas (grade 1 or 2). Ten died before receiving any treatment, and a further seven died within 28 days of surgery, leaving 143 children whose survival in relation to treatment modality is the subject of this paper. Low-grade astrocytomas are responsive to radiation therapy. This treatment has no clear benefit to offer children with superficial tumours that can be resected completely or nearly so, but significantly improves survival rates when tumours are deep-seated and not amenable to excision.
Keywords:Low-grade astrocytomas  Radiotherapy
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