Radiofrequency ablation of lung metastases: factors influencing success |
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Authors: | Alice R Gillams William R Lees |
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Institution: | (1) Department of Medical Imaging, University College Hospital and University College London Medical School, London, UK;(2) Special Xray, Podium 2, University College Hospital, 235, Euston Road, London, NW1 2BU, UK |
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Abstract: | This paper analyses the factors associated with successful radiofrequency ablation (RFA) of lung metastases. The study group
comprised 37 patients 19 female, mean age 61 (34–83)] with 72 metastases who had follow-up CT scans available for analysis
and for those with no recurrence >6 months follow-up. Internally cooled electrodes were used in 64 and expandable electrodes
in 8. The tumour size and location, electrode type, number of ablations, duration of ablation, year of treatment and tumour
contact with vessels larger than 3 mm were recorded. The mean tumour diameter was 1.8 cm (0.4–6.6 cm). Mean follow-up in those
without recurrence was 13.1 months (6–48). Recurrence was common in larger tumours, occurring in 7/7 (100%) tumours >3.5 cm
compared with 18/65 (28%) ≤ 3.5 cm (P < 0.01). Recurrence occurred in 14/24 (58%) tumours in direct contact with large vessels compared with 11/48 (23%) of the
remainder (P = 0.04). On multivariate analysis, size was the dominant feature (P = 0.013); vessel contact and peripheral location did not reach significance (P = 0.056 and 0.054 respectively). Peripheral tumours less than 3.5 cm with no large vessel contact are the optimal tumours
for RFA. |
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Keywords: | Radiofrequency ablation Lung metastases Thermal ablation |
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