非小细胞肺癌的中医证型与血清肿瘤标志物关系的临床研究

目的：研究非小细胞肺癌的辨证分型与血清肿瘤标志物的关系,探讨血清肿瘤标志物能否为非小细胞肺癌患者的中医分型提供一个辅助的客观依据。方法：观察62例第1次住院治疗并经病理证实的非小细胞肺癌患者,采用放射免疫法检测患者血清CEA、CA125、CA153及CA199的浓度。计算4种血清肿瘤标志物的浓度倍数,并计算其在不同组合（二联、三联及四联）中的百分含量,研究其在不同证型中的表达是否存在差异性。结果：各型的人数分布存在差异,其中气虚痰湿型最多（45.16%）,阴虚痰热型（25.81%）与肺郁痰瘀型（22.58%）相当,气阴两虚型（6.45%）最少。CEA在CEA与CA125的二联组合中的百分含量、CEA在CEA、CA125与CA153的三联组合中的百分含量、CA125在CEA、CA125与CA153的三联组合中的百分含量及CA125在四联组合中的百分含量在四个证型之间的表达存在差异性,这种差异具有统计学意义（P〈0.05）。结论：血清肿瘤标志物可作为非小细胞肺癌中医分型的一个辅助的客观依据。

Clinical Research on the Relationship between the Traditional Chinese Medicine Syndrome Type and Serum Tumor Marker of Non-smail-ceU Carcinoma

Objective：To study the relationship between the traditional Chinese medicine （TCM） syndrome type and serum tumor marker of nonsmallcell carcinoma, and explore whether serum tumor marker can provide an assistant objective basis for the TCM syndrome type of nonsmallcell carcinoma. Methods ：62 patients who were first time admitted in hospital and were proved as nonsmallcell carci noma by pathology were observed and densities of CEA,CA125, CA153 and CA199 of serum were detected by radioimmunoassay. Then the density multiple of four kinds of serum tumor marker and the percentage composition of serum tumor marker in different combina tions （bigeminy, trigeminy and quadrigiminy） were counted, so as to research whether the expression of serum tumor marker in different syndrome types existed difference or not. Results：Distribution of number of people in every type existed differences, among which, the number of patients in the syndrome type of qideficiency and phlegmdampness was the most （45.16%） ,the number of patients in the syndrome type of yindeficiency and phlegmheat （25.81%） was similar to the syndrome type of depression of lung and stagnation of phlegm （22.58%） ,and the number of patients in the syndrome type of both qi and yin deficiency was the least（＆ 45% ）. Percentage composition of CEA in the bigeminy combination of CEA and CA125, percentage composition of CEA in the trigeminy combination of CEA, CA125 and CA153 ,percentage composition of CA125 in the trigeminy combination of CEA, CA125 and CA153 and percentage composition of CA125 in the quadrigeminy combination in the expression of four kinds of syndrome types existed difference, which had statistic significance （ P 〈 0.05 ）. Conclusion ： Serum tumor marker can be eonsidered as an assistant objective basis for the TCM syn drome type of nonsmallcell carcinoma.