安度更年汤联合尼尔雌醇治疗围绝经期综合征临床研究

目的：探讨安度更年汤联合尼尔雌醇治疗围绝经期综合征的临床疗效。方法：将57例患者随机分为治疗组和对照组。治疗组30例用安度更年汤联合尼尔雌醇片治疗;对照组27例用尼尔雌醇片同时服用维生素E、维生素C、维生素B1、谷维素和钙剂,3个月为1疗程。治疗前后应用B型超声检测子宫内膜情况,检查肝、肾功能、血清E2水平。结果：两组用药后围绝经期症状均明显改善。治疗组控制围绝经期症状的疗效优于对照组（P〈0.05）,且不良反应较少。治疗后血清E2水平治疗组高于对照组（P〈0.05）。子宫内膜厚度前后无明显变化（P〉0.05）。结论：安度更年汤联合尼尔雌醇能有效控制围绝经期综合征的症状且安全可靠,明显优于单纯使用西药,是一种较理想的治疗方法。

Clinical Study on the Treatment of Perimenopausal Syndrome by Integration of Andu Gengnian Tang with Nilestriol Tablets

Objective：To explore clinical therapeutic effects of integration of Andu Gengnian Tang with Nilestriol Tablets on the treatment of perimenopausal syndrome.Methods：57 cases were randomly divided into the treatment group and the control group.The treatment group was given Andu Gengnian Tang with a combination of Nilestriol Tablets,while the control group was given western medicine of Nilestriol Tablets,Vitamin E,Vitamin C,Vitamin B1,oryzanol and calcium,with a treatment course of three months.Endometrium was inspected through B-mode ultrasonography and functions of kidney and liver,level of serum E2 were examined before and after treatment respectively.Results：Symptoms of perimenopause in both groups were obviously improved after given medicine.Curative effect of the treatment group was superior to the control group in controlling the symptom of perimenopause（P0.05）,and had little adverse effect.Level of serum E2 in the treatment group was higher than the control group（P0.05）.Thickness of endometrium had no obviously change before and after the treatment（P0.05）.Conclusion：Integration of Andu Gengnian Tang with Nilestriol Tablets can effectively control the symptom of perimenopause with safety and reliability,which is significantly superior to the single application of western medicine,so it is a kind of quite perfect therapy.