慢性阻塞性肺疾病中医辨证分型与实验室指标相关性研究

目的：探讨慢性阻塞性肺疾病（COPD）中医辨证分型与白细胞计数、肺功能、血气分析的相关性研究。方法：通过对北京丰台医院近2a来200例COPD急性加重期患者观察,根据临床常见的4个证型与相关性分析,研究COPD急性加重期中医辨证分型与实验室指标之间的内在联系。结果：白细胞计数：痰热壅肺型COPD与阳虚水停型COPD比较,差异有统计学意义（P〈0.05）;中性粒细胞百分比（%）：痰热壅肺型COPD与阳虚水停型COPD比较,差异有统计学意义（P〈0.05）;FEV1、FEV1/FVC%等大部分常规肺功能指标明显低于对照组,风寒束肺型COPD与痰浊阻肺型COPD、阳虚水停型COPD比较,差异均有统计学意义（P〈0.05）;血气分析各指标比较,PaO2在风寒束肺型COPD与痰浊阻肺型COPD、阳虚水停型COPD比较,均有显著性差异（P〈0.05）;PaCO2在阳虚水停型COPD与风寒束肺型COPD比较,差异均有统计学意义（P〈0.05）。结论：白细胞计数、中性粒细胞百分比（%）、FEV1、FEV1/FVC%、PaO2、PaCO2可以作为COPD中医辨证分型的参考指标。

Correlation Research of Chronic Obstructive Pulmonary Disease and Syndrome Differentiation of Traditional Chinese Medicine and Laboratory Indexes

Objective：To investigate the the correlation study of chronic obstructive pulmonary disease with syndrome differentiation and blood cell counts,pulmonary function,blood gas analysis.Methods：through 200 patients with acute exacerbations of COPD of Beijing Fengtai Hospital in recent 2 years,according to the common four clinical syndromes and correlation analysis,study the intrinsic link of acute exacerbation of COPD syndrome differentiation of traditional Chinese medicine between laboratory index.Results：The white blood cell count in phlegm heat obstructing lung type with Yang deficiency water stop type was significantly different（P0.05）;the neutrophil percentage（%） of phlegm heat obstructing lung type with Yang deficiency water stop type was significantly different（P0.05）;FEV1,FEvl/Fvc% and most other conventional lung function index was significantly lower than the control group,chill bunches of lung and phlegm-turbidity-in-lung type,Yang deficiency water stop type was significantly different（P0.05）;blood qi analysis comparison of parameters,PaO2 in chill bunches of lung and phlegm-turbidity-in-lung type,Yang deficiency water stop type was significantly different（P0.05）;PaCO2 in Yang water stop and chill bunches of lung type was significantly different（P0.05）.Conclusion：The white blood cell count,neutrophil percentage（%）,FEV1,FEvl/Fvc%,PaO2,PaCO2 can be used as chronic obstructive pulmonary disease and syndrome differentiation of Chinese medicine reference index.