中西医结合治疗狼疮性肾炎临床研究

目的：探讨中西医结合治疗狼疮性肾炎的临床疗效。方法：将58例狼疮性肾炎患者随机分为对照组与治疗组各29例。对照组采用甲泼尼松龙及环磷酰胺冲击治疗。治疗组在对照组基础上依据激素及环磷酰胺（CTX）用药的不同阶段配合中医辨证论治,观察治疗后24个月的ds-DNA、补体C3、24 h尿蛋白、血清白蛋白、肾功能等变化情况,同时观察应用激素及CTX期间不良反应情况。结果：两组疗效比较,治疗组完全缓解6例（20.7%）,显著缓解16例（55.2%）,部分缓解6例（20.7%）,无效1例（3.4%）;对照组：完全缓解3例（10.3%）,显著缓解8例（27.6%）,部分缓解6例（20.7%）,无效2例（6.9%）,两组疗效比较,差异有统计学意义（P〈0.05）。两组实验室指标比较,治疗组明显优于对照组（P〈0.01）;两组激素不良反应比较,治疗组较对照组明显减少（P〈0.01）。结论：中西医结合治疗狼疮性肾炎疗效显著。

Clinical Study on the Treatment of Lupus Nephritis by Integration of Traditioanal Chinese Medicine and Western Medicine

Objective：To explore the clinical curative effects of integration of TCM and Western medicine on the treatment of lupus nephritis.Methods：58 patients were randomly divided into the control group and the treatment group with each of 29 cases.The control group was given Methylprednisolone and Cyclophosphamide.The treatment group was given TCM syndrome differentiation and treatment based on the treatment of control group according to different stages of using Methylprednisolone and Cyclophosphamide.The variation of ds-DNA,complementC3,urine protein in 24 hours,serum albumin,function of kidney were observed after a treatment of 24 months,and the side effects during the application of hormone and CTX were observed.Results：Therapeutic effects of both groups were compared.Among 29 cases in the treatment group,6 cases obtained complete relief（20.7%）,16 cases were significantly relieved（55.2%）,6 cases were partially relieved（20.7%） and 1 case was ineffective（3.4%）;Among 29 cases in the the control group,3 cases obtained complete relief（10.3%）,8 cases were significantly relieved（27.6%）,6 cases were partially relieved（20.7%） and 2 case was ineffective（6.9%）.Comparion of the therapeutic effects of both groups showed the difference was statistically significant.Laboratory indicators in the treatment group was significant superior to the control group（P0.01）;side effects of hormone in the treatment group were obviously reduced compared with the control group（P0.01）.Conclusion：Integration of TCM and Western medicine has notable effect in the treatment of lupus nephritis.