电针对恶性肿瘤化疗后神经毒性反应影响

目的：观察电针对恶性肿瘤化疗后神经毒性的防治作用。方法：运用随机交叉对照试验的研究方法将40例患者随机分为A、B两组，在化疗基础上，按不同顺序分别采用口服中药＋电针治疗及单纯口服中药治疗。编号为第1个疗程A1、B1组，第2个疗程A2、B2组，其中A1、B2为试验组（共40例）采用化疗＋电针＋中药措施治疗，B1、A2为对照组（共40例），采用化疗＋中药措施治疗。比较两组在降低神经毒性、体质量及生存质量的差别。结果：在降低神经毒性方面，两组治疗前后比较，神经毒性发生率均有显著性差异（P〈0．05）；两组间治疗后比较，差异也有统计学意义（P〈0．05）。功能状态疗效方面，两组治疗后免疫功能各项指标较治疗前均有显著改善（P〈。0．05），治疗后Karnorfsy评分、生存质量评分及体质量变化各项指标与治疗前比较，差异均有统计学意义（P〈0．05），其中Karnorfsy评分、生存质量评分试验组与对照组治疗后组间比较，差异也有统计学意义（P〈0．05）。结论：电针加中药治疗恶性肿瘤在改善化疗后引起的神经毒性以及Karnofsky评分、生存质量评分均优于单纯中药治疗．提示该方法具有增效减毒之功效，并可改善恶性肿瘤患者的体质量，提高免疫力。

Effect on the Prevention and Treatment of Neurotoxicity of Malignant Tumor by Electroacupuncture after Chemotherapy

Objective：To observe the function of electro-acupuncture in preventing and treating neurotoxicity of malignant tumor after chemotherapy. Methods ：40 cases were randomly divided into A and B groups by the method of randomized crossover controlled trial. Group A and B were given Chinese medicine plus electro-acupuncture treatment and pure Chinese medicine treatment according to dif- ferent sequences on the basis of chemotherapy. The first treatment course was numbered group A1 and B1 and the second was numbered group A2 and B2 ;the experiment group A1 and B2 （a total number of 40 cases） were given chemotherapy plus electro-acupuncture plus Chinese medicine measures treatment, and the control group B1 and A2 （a total number of 40 eases） were given chemotherapy and Chinese medicine treatment. Then the differences of neurotoxicity reduction,weight and quality of life between two groups were compared. Results ： In reducing neurotoxicity,comparison of neurotoxicity incidence rate before and after treatment in two groups showed both had significant difference （P 〈 0.05 ） ;comparison among two groups after treatment showed the difference was also significant （P 〈 0.05 ）. In functional status and curative efficacy, the indicators of immune function after treatment of both groups were improved compared with before treatment（P 〈 0.05 ）,while among the indicators, compared with the control group,variations of Karnorfsy score,quality of life scores and weight after treatment in the experiment group had significant difference （ P 〈 0.05） ; comparison of Karnorfsy score and life quality score between the experimental group and control group after treatment showed the difference was also significant（P 〈 0.05 ）. Conclusion：Electro-acupuncture combined with traditional Chinese medicine treatment was superior to the single use of Chinese medicine treatment in treating malignant tumor and improving chemotherapy-induced neurotoxicity, Karnofsky score and quality of life scores, which indicates that this method has effects on increasing curative effects, decreasing toxicity, improving weight of patients with malignant tumors and enhancing immunity.