| 海带多糖对应激小鼠脑组织SOD、MDA的影响 |
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| 引用本文： | 梁桂宁,谢露,梁志锋,胡世风,王小玲. 海带多糖对应激小鼠脑组织SOD、MDA的影响[J]. 右江民族医学院学报, 2006, 28(3): 333-334 |
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| 作者姓名： | 梁桂宁 谢露 梁志锋 胡世风 王小玲 |
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| 作者单位： | 广西医科大学生理学教研室,广西,南宁,530021 |
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| 摘 要： | 目的探讨海带多糖在应激状态下对小鼠脑组织脂质过氧化物反应的影响。方法随机将40只小鼠分为正常组、对照组、低剂量给药组和高剂量给药组,皮下注射肾上腺素和耐力游泳制造应激模型后,取小鼠脑组织测定超氧化物歧化酶(SOD)和丙二醛(MDA)。结果不同剂量的海带多糖均能降低MDA的含量(P<0.05),并能增加SOD的活性(P<0.05)。结论海带多糖具有抗脂质过氧化保护脑组织的作用。
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| 关 键 词： | 海带多糖 脂质过氧化作用 氧化性应激 氧化物 丙二醛 小鼠 动物实验 |
| 文章编号： | 1001-5817（2006）03-0333-02 |
| 收稿时间： | 2006-02-16 |
| 修稿时间： | 2006-02-16 |
The effect of laminarin on SOD and MDA in irritated mice brain tissues |
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| LIANG Gui-ning,XIE LU,LIANG Zhi-feng,HU Shi-feng,WANG Xiao-ling. The effect of laminarin on SOD and MDA in irritated mice brain tissues[J]. Journal of Youjiang Medical College For Nationalities, 2006, 28(3): 333-334 |
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| Authors: | LIANG Gui-ning XIE LU LIANG Zhi-feng HU Shi-feng WANG Xiao-ling |
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| Affiliation: | Department of Physiology, Guangxi Medical University, Nanning , Guangxi 530021, P. R. China |
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| Abstract: | Objective To outline the clinical outcomes of laminarin affecting the lipid peroxides in mice tissues in the irritable state.Methods Forty mice were randomized to a normal group,a control group,a low dosage group and a high dosage group.The mice irritated models were obtained by subcutaneous injection with adrenalin and conducting endurance swimming test in mice,then superoxide dismutase(SOD) and malondialdehyde(MDA) in the mice brain tissues were measured.Results Decreased MDA levels were found in different dosage of laminarin groups(P<0.05),and an increased SOD activity were obtained(P<0.05).Conclusion Laminarin has anti-lipid peroxidation which is effective in protecting the brain tissues. |
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| Keywords: | laminarin lipid peroxidation oxidative stress oxides malondialdehyde mice animal experimentation |
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